As expected, mipomersen also resulted in significant reductions in app B, total cholesterol, and non-HDL cholesterol.
Niacin is a vitamin that can raise the level of HDL cholesterol (the good type).
He points out that patients received the drug, a mutation of HDL cholesterol, for only five weeks.
Pfizer's torcetrapib, when given in combination with Lipitor, has boosted good HDL cholesterol by about 60% in midstage studies.
The idea that a version of HDL cholesterol could actually decrease the amount of plaque in arteries is a big step forward.
They're trying to figure out whether the problems with torcetrapib come from lowering HDL cholesterol, lowering a particular type of HDL cholesterol, or from some unique characteristic of the torcetrapib molecule itself.
Another Zetia benefit: In studies, some patients not only saw "bad" LDL cholesterol decrease, they also saw a slight increase in "good" HDL cholesterol, which is thought to be better for health.
Pfizer, Eli Lilly, Bristol-Myers Squibb, AstraZeneca and others are testing drugs that would reduce inflammation indirectly by raising the "good" HDL cholesterol that helps the body pump fat out of the arteries.
Alan Tall of Columbia University says the results were "interesting and exciting, " and, moreover, were a "proof of concept" for the idea that raising HDL cholesterol can move plaque out of the arteries.
The large doses of fructose from both sucrose (table sugar) and high fructose corn syrup may be particularly detrimental to your health as they can cause the accumulation of metabolically toxic belly fat, cholesterol abnormalities -- including high triglycerides and reduced levels of HDL (good cholesterol) -- and nonalcoholic associated fatty liver disease.
While the shrimp diet did increase people's so-called bad cholesterol or LDL slightly, it also boosted their so-called good cholesterol or HDL enough to offset the increase in bad cholesterol.
An experimental Pfizer drug designed to raise HDL (good cholesterol) recently increased mortality in a large clinical trial.
Scientists have also speculated that the kind of HDL "good cholesterol" made by a drug like torcetrapib might be dysfunctional.
The mutation carriers had less artery calcification, indicating that they had healthier hearts as well as higher HDL (good cholesterol), and lower triglycerides and LDL (bad cholesterol).
CNN: Gene mutation protects against milk shakes and other fatty fare
Now in human trials, it is the first in a wave of drugs that aim to raise so-called good cholesterol, or HDL, the protein that helps truck chunks of cholesterol away from the arteries.
High-density lipoprotein, better known as HDL or "good cholesterol, " has become a medical mainstay.
Last November Pfizer announced the failure of torcetrapib, a drug to boost good cholesterol (HDL).
Apo A-1 is thought to be the key HDL component that removes cholesterol from cells.
FORBES: Early Look: New Methods To Enhance Cholesterol Efflux
Also on tap, a new form of niacin, the only drug now available to raise HDL (the good cholesterol).
Last November Pfizer (nyse: PFE - news - people ) announced the failure of torcetrapib, a drug to boost good cholesterol (HDL).
Its entry, torcetrapib, which is being combined with Lipitor, aims to raise the level of "good" HDL, which trucks cholesterol from the arteries back to the liver.
Data to be presented Sunday at a medical conference in Vienna show that Cordaptive cuts bad cholesterol, the stuff that sticks to arteries, by 21% and boosts the artery-cleansing good cholesterol (HDL), according to several Wall Street analysts.
Alcohol, including beer, in moderation raises high-density lipoprotein or HDL, known as good cholesterol, says Dr. R.
The study also found some improvement in HDL or "good" cholesterol in those who took up drinking.
Researchers theorize that medically elevated HDL may not be as effective as natural HDL at whisking away bad cholesterol.
Fifty is the good cholesterol, the HDL -- that should be above 50.
The addition of Kynamro helps to reduce low-density lipoprotein-cholesterol (LDL-C), apolipoprotein B, total cholesterol, and non-high density lipoprotein-cholesterol (non HDL-C).
FORBES: FDA Approves Mipomersen For Homozygous Familial Hypercholesterolemia
The idea was that Cordaptive was basically just niacin, a B vitamin that's known to raise the good cholesterol, or HDL, and cuts the bad.
These post-menopausal women had somewhat high LDL ("bad" cholesterol), but they were otherwise healthy, with an average age of 56 (that's young) and an average HDL ("good" cholesterol) of 67 (that's high).
Another potential beneficiary is Kos Pharmaceuticals, which makes a preparation of niacin to raise good cholesterol, or HDL. Patients on Crestor in this trial had a surprisingly big jump in HDL. The big question is how much doctors will embrace this single study.
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