It is supposed to be much more difficult to show a benefit in the "hard events"--heart attack, stroke and death--than in the broader swath of "extra" heart problems that AtheroGenics measured in its trial.
"The new APC trial confirms that the safety issue--heart attack and stroke risk---is one that applies to the whole class of Cox-2 inhibitors, " says Eric Topol , chairman of cardiology at the Cleveland Clinic.
The strong advice - from these researchers and from other experts - is that those WITH a history of cardiovascular disease - such as heart attack or stroke - should continue with daily aspirin.
Being overweight increases the risks of heart disease and stroke - the biggest killers of men.
According to a press release issued to reporters, 13.2% of the patients receiving Tredaptive had a heart attack, heart-related death, stroke, or need for a stent procedure or bypass surgery.
's (nyse: PFE - news - people ) Lipitor or Merck 's (nyse: MRK - news - people ) Zocor cut the odds of heart attack or stroke in high-risk patients by a third, but they also can cause side effects that destroy muscle tissue and, eventually, the liver.
While niacin showed no difference from placebo in the death rate of the men in this study, fewer patients on niacin had a non-fatal heart attack or stroke, by 26% and 24%, respectively.
The U.S. Food and Drug Administration today approved the anti-clotting drug Xarelto rivaroxaban to reduce the risk of stroke in people who have abnormal heart rhythm non-valvular atrial fibrillation.
Considering that Pol Pot was about 73 and had a history of ill health -- in recent years, he suffered a minor stroke and had cardiac problems -- a heart failure is perfectly feasible.
At the end of the study, 3.8% of the Mediterranean-diet-plus-olive-oil and 3.4% of the Mediterranean-diet-plus-nuts groups suffered a heart attack, stroke or death from cardiovascular disease.
WSJ: Mediterranean Diet of Olive Oil, Nuts, Reduces Heart Disease, Study Finds
Pfizer 's (nyse: PFE - news - people ) Bextra, which increased the risk of heart attack and stroke in patients undergoing open heart surgery, and Arcoxia, Merck's (nyse: MRK - news - people ) still experimental follow-up to Vioxx, are the focus of a great deal of concern.
In a study published last year in the American Heart Association journal Circulation: Cardiovascular Quality and Outcomes, African-Americans with heart disease who practiced Transcendental Meditation regularly were 48% less likely to have a heart attack or stroke, or to die, than those who attended a health-education class.
Researchers found that participants taking Crestor cut their risk of heart attack, stroke and death by nearly half -- 44 percent -- compared with participants taking the placebo.
CNN: Study: Cholesterol drugs could help those with healthy levels
Aspirin can also be used as a long term treatment for those with a history of heart attack and stroke, or who have peripheral arterial disease, stable angina or atrial fibrillation - an irregular heart rhythm.
Others tackled heart disease, stroke, and drug abuse and HIV - all of which disproportionately affect the black community.
That means that these kids are at greater risk of obesity-related diseases -- you name them, cancer, heart disease, stroke.
WHITEHOUSE: First Lady Michelle Obama at ��Chefs Move to Schools�� Event
Vioxx, the blockbuster arthritis pill, was pulled from the market after a study showed that long-term use doubled the risk of heart attack and stroke.
But in 1999, the year Vioxx hit pharmacy shelves, a University of Pennsylvania scientist named Garret FitzGerald was already arguing that blocking only Cox-2 might raise the risk of heart attack and stroke.
That is the tragedy at the heart of our health care system -- The devastation when one stroke of bad luck undoes a lifetime of hard work.
Merck and Schering-Plough have one trial testing whether Zetia prevents heart attack and stroke, and the study is not expected to end until 2012.
In December, Pfizer said that a government-funded study testing whether Celebrex could prevent colon polyps instead showed that long-term use of Celebrex doubled the risk of heart attack and stroke.
The 6, 000-patient study was designed to show that AtheroGenics' drug, known by the code name AGI-1067, decreased the risk not only of heart attack, stroke and death but also of less important heart problems, including stent procedures, bypass surgery and chest pain.
Wright's friend Rick Hession has a heart condition that could cause a stroke, but he has a three-month wait or more for an operation to help correct it.
Doug Springsteen died in 1998, at seventy-three, after years of illness, including a stroke and heart disease.
's (nyse: PFE - news - people ) Celebrex, which doubled the risk of heart attack and stroke.
He says a longevity-gene drug, shielding patients simultaneously from mental deterioration, heart disease and stroke, could be ready in less than a decade.
Low-dose aspirin is already recommended to cut the risk of heart attack and stroke, but there are no national guidelines on who should consider taking it to prevent cancer, or how much to take.
If we can help people do more physical exercise - especially when they are at risk of illness or recovering from it - we can cut the number of deaths from conditions like heart disease and stroke.
The team of researchers, led by Dr Anastasis Stephanou, carried out laboratory tests on heart cells which found that a major chemical component of green tea known as epigallocatechin-3-gallate (EGCG) can reduce cell death after a heart attack or stroke.
However, statin pre-treatment had no influence on the risk of dying, stroke, heart attack or kidney failure around the time of the operation.
FORBES: Preoperative Statins Found to Reduce AF and Length of Stay But Not Mortality
应用推荐