The insurance company denied the referral, claiming that it would only be appropriate if a diagnosis of heart valve disease had been made.

FORBES: The Health Insurer Could Be A Better Friend

Drugs that stimulate the next subtype, the 5-HT2B receptor, have been associated with heart valve disease, the major reason for withdrawal of the fenfluramine part of the fen-phen weight loss combination drug.

FORBES: Why Does Arena's Obesity Drug Have Abuse Potential?

In SEAS, Vytorin failed to do better than placebo at treating a heart valve disease called aortic stenosis, but it did reduce the risk of heart attacks, strokes and operations to unclog arteries.

FORBES: Efficacy Questions Still Dog Vytorin

Defenders of Vytorin say that another study of the drug in an artery valve disease provides evidence that the drug reduces heart attacks.

FORBES: Magazine Article

Edwards Lifesciences Corp. a leader in advanced cardiovascular disease treatments, is the number-one heart valve company in the world and the global leader in acute hemodynamic monitoring.

FORBES: 52-Week High Companies

The study from the Centers for Disease Control and Prevention found IVF babies suffered from higher rates of conditions such as heart valve defects, cleft lip and palate, and digestive system abnormalities.

BBC: New guidance on IVF defects risk