The addition of Kynamro helps to reduce low-density lipoprotein-cholesterol (LDL-C), apolipoprotein B, total cholesterol, and non-high density lipoprotein-cholesterol (non HDL-C).
FORBES: FDA Approves Mipomersen For Homozygous Familial Hypercholesterolemia
Doctors knew that high-powered cholesterol-lowering drugs like Lipitor, called statins, cut the chance of heart attacks by about one-third.
But many nutritionists are quick to note that diets high in certain fats - and high in cholesterol - are believed to drive up the risks of heart disease, type 2 diabetes and some forms of cancer.
For decades doctors and scientists obsessed over one key factor in heart attacks--high cholesterol--and devised drugs to treat it.
KYNAMRO, given as a 200 mg weekly subcutaneous injection, has been approved as an adjunct to lipid-lowering medications and diet to reduce low density lipoprotein-cholesterol (LDL-C), apolipoprotein B (Apo B), total cholesterol (TC), and non-high density lipoprotein-cholesterol (non HDL-C) in patients with homozygous familial hypercholesterolemia (HoFH).
FORBES: FDA Approves Mipomersen For Homozygous Familial Hypercholesterolemia
He argues that insurers must provide physicians and patients first line access to at least one high-powered cholesterol drug.
This morning, Merck announced that Zocor is still the only high-powered cholesterol drug that will be bought by the U.S. Department of Veteran Affairs and the Department of Defense for their employees.
Moreover, some of the negative health effects of a poor diet--such as hypertension, diabetes and high cholesterol--can be handled with drugs.
He looked at a number of studies that showed in patients treated with genetically super-high cholesterol who'd been treated, it was getting difficult to show a difference in artery thickness.
Last night, the Food and Drug Administration announced the approval of Kynamro, a new drug to lower cholesterol in patients with homozygous familial hypercholesterolemia (HoFH), a rare genetic disease that causes sky-high cholesterol levels and heart attacks at a young age.
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Torcetrapib aims to raise good cholesterol, or high-density lipoprotein, by blocking the cholesterol ester transfer protein.
The large doses of fructose from both sucrose (table sugar) and high fructose corn syrup may be particularly detrimental to your health as they can cause the accumulation of metabolically toxic belly fat, cholesterol abnormalities -- including high triglycerides and reduced levels of HDL (good cholesterol) -- and nonalcoholic associated fatty liver disease.
It also lowered the so-called good cholesterol, or high-density lipoprotein (HDL), and it did not enter the cell, a characteristic Medford wanted hisdrug to have, because some of the oxidation process takes place within cellular membranes.
One reason Isis needs money is the company plans to launch a study next year in patients with garden-variety high cholesterol.
And while existing medicines like Lipitor, Vytorin and Crestor aren't enough for some FH patients, they work well for most patients with run-of-the-mill high cholesterol.
ETC-216 is a slightly different version of a protein in high-density lipoprotein, the so-called good cholesterol.
Among them were the highly touted cholesterol drug Tredaptive and a combo pill for patients with diabetes and high cholesterol called MK-0431E.
It was originally dropped as a treatment for high cholesterol by Bristol-Myers Squibb because of the liver toxicity issues, but a University of Pennsylvania cardiologist, Daniel Rader, championed the drug, leading Aegerion to develop it.
FORBES: Aegerion Cholesterol Drug Approved. Will It Treat 300 Patients, Or 3,000?
Diabetes UK says that because of the existence of statins - cholesterol-lowering drugs - it is relatively easy to control high cholesterol.
Blumenthal thinks Zetia is still a good option for people who need high doses of the lifesaving cholesterol-lowering drugs called statins, including Lipitor, Zocor and Crestor, but won't take them because of side effects.
The study's statistician, Harvard University's Robert Glynn, estimates that about 250, 000 heart attacks, strokes, hospitalizations and cardiac deaths could be prevented over five years if people with good cholesterol and high hs-CRP levels were taking statins.
CNN: Study: Cholesterol drugs could help those with healthy levels
In Ridker's study, patients with high bad cholesterol, or low-density lipoprotein and high CRP had heart attacks, strokes or heart procedures 9.9% of the time compared with 4.9% of the time for patients where both risks were low.
In the study where it helped patients lose weight, the drug also raised good cholesterol, or high-density lipoprotein (HDL), by 23%, almost as much as Niaspan, the sustained-release niacin drug made by Kos Pharmaceuticals (nasdaq: KOSP - news - people ) that is the main currently available treatment for raising HDL. Rimonabont also cut triglycerides, another risk factor for heart disease, by 16%.
Various health studies have shown that eating a handful of almonds every day -- a food high in magnesium, Vitamin E and B2 -- can lower cholesterol and help reduce the risk of heart disease.
By June, it will lose patent protection on four drugs--Vasotec and Prinivil for hypertension, Mevacor for high cholesterol and Prilosec, which it shares with AstraZeneca (nyse: AZN - news - people), for ulcers.
Low-density lipoprotein (LDL) or bad cholesterol levels should be below 100, and high-density lipoprotein (HDL) should measure 35 or above.
Researchers looked at six groups of eight-week-old mice with high levels of cholesterol over 18 weeks.
Nothing on the market today increases "good cholesterol, " or high-density lipoprotein (HDL), as much as torcetrapib did in early clinical trials.
As scientists understand the disease better, they will begin to treat it as any other chronic disease--such as diabetes or high cholesterol.
To reach this goal Harvard's Ridker is leading a 15, 000-patient trial testing whether AstraZeneca's statin drug, Crestor, can prevent heart attacks in patients with normal cholesterol levels but high C-reactive protein levels.
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