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Andriy Pyatov saved Ibrahim Afellay's shot as the visitors eased through 1-0.
BBC: Shakhtar 0-1 Barcelona (agg 1-6)
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While Spurs regrouped after that second substitution, Ibrahim Afellay came close to giving PSV with the lead when his shot was beaten away by Robinson.
BBC: PSV 0-1 Tottenham (1-1)
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But the second half followed much the same pattern as the first, and Ibrahim Afellay should have made it 2-0 when he sliced wide from 20 yards.
BBC: Tottenham 0-1 PSV