Established drugs includes the antibiotic Clarithromycin and the prescription painkiller Brufen, a version of ibuprofen.
It's not clear, some say, that even old drugs such as ibuprofen are necessarily safe.
Older drugs such as ibuprofen cause stomach problems in part because they inhibit both enzymes.
Pain relievers such as aspirin, ibuprofen and acetaminophen all can stave off hangover headaches.
Over-the-counter nonsteroidal anti-inflammatory drugs such as aspirin, naproxen and ibuprofen offer relief to some patients.
The risk of serious complications from aspirin and ibuprofen, including bleeding ulcers, is 7 per thousand.
Drinking plenty of fluids, taking acetaminophen or ibuprofen for fever and resting are recommended.
Now the modern day equivalent is 'take two ibuprofen and call me in the morning'.
Most scientists have credited ibuprofen's anti-Alzheimer's affect to the same mechanism the drug uses to calm swelling.
Widely-used pain medications like ibuprofen and naproxen can, in rare cases, cause ulcers in the stomach or intestines.
Celebrex treats pain as well as other NSAIDS, or non-steroidal anti-inflammatory drugs, such as ibuprofen, naproxen and aspirin.
It is also possible that older painkillers like ibuprofen and naproxen were studied less rigorously that Vioxx and Celebrex.
Farkouh also points out that in the trial, Prexige seemed safer than ibuprofen.
There are 20 other arthritis pills already available, including ibuprofen, naproxen and diclofenac.
Prescriptions for non-steroidal anti-inflammatory drugs in Denmark are for relatively large doses, equivalent to 400mg or 600mg of ibuprofen.
Part of the reason for this distinction was that the Celebrex cardiovascular data mirrored that of NSAIDs like naproxen and ibuprofen.
FORBES: Vioxx and Diclofenac: Why Are Two Heart Risky Pain Drugs Viewed Differently?
One criticism of the Cox-2 class so far has been that these drugs are no better at killing pain than ibuprofen.
Dr Stuttaford says our reliance on drugs like ibuprofen goes hand in hand in the UK with the decline in GP services.
Or take for example the use of ibuprofen as an arthritis medication.
Mrs Jones's statement earlier outlined how April had a mild form of cerebral palsy and took ibuprofen and paracetamol to manage her pain.
For arthritis drugs, data is most likely to come from a Pfizer-sponsored study comparing the heart safety of Celebrex with ibuprofen and naproxen.
Pfizer has enlisted Nissen to conduct a giant study comparing Celebrex, ibuprofen and naproxen, but results are not expected until at least 2009.
In the regulatory firestorm that followed, researchers pointed at other arthritis drugs, including Pfizer 's Celebrex and ibuprofen, as also causing cardiovascular risk.
The pain can be mild and treated with a mild pain medicine such as ibuprofen or a very noticeable ache that requires narcotics.
The hearing was told that during police interviews, Ms Leighton claimed staff regularly took drugs such as the painkiller ibuprofen for their own use.
His neck was giving him no trouble on the day, although he had taken ibuprofen for a sore back in the morning, she said.
Some were given a regular dose of the type of painkillers called "non-steroidal anti-inflammatories" - which include ibuprofen and aspirin, while the rest were not.
This may range from Tylenol or ibuprofen to narcotic pain medications, said Dr. Marianne Cinat, director of the University of California, Irvine, Regional Burn Center.
They aim to provide the same pain relief as older anti-inflammatory medicines such as ibuprofen, without the older drugs' tendency to occasionally cause nasty ulcers.
Nonsteroidal anti-inflammatory painkillers such as ibuprofen work for some migraine sufferers.
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