In large doses, mercury contamination can affect the health and populations of fish and wildlife, as it harms their central nervous and reproductive systems.

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However, the research clearly shows, in large doses, these habits do become deadly and they begin to lead CEOs to exhibit the other habits as well.

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All sorts of substances will cause cancer if given to rats in large enough doses.

ECONOMIST: The environment

Prescriptions for non-steroidal anti-inflammatory drugs in Denmark are for relatively large doses, equivalent to 400mg or 600mg of ibuprofen.

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Dr Robert Waldman testified that records from Jackson's dermatologist show the singer was receiving large doses of the drug in the months ahead of his death.

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Its cofounder, Harvard biologist David Sinclair, had published studies showing evidence that large doses of the resveratrol chemical in red wine extends the lives of fat mice.

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