"Angiogenesis inhibitors remain a promising new way to attack cancer, " said Lee Rosen , M.
Aromatase inhibitors like AstraZeneca (nyse: AZN)'s tamoxifen were revolutionary in the treatment of breast cancer.
Scientists then tested a class of drugs called histone deacetylase, or HDAC, inhibitors on the mice.
In animal tests Guilford's PARP inhibitors can reduce stroke-induced brain damage by up to 70%.
These "cholinesterase inhibitors" include tacrine (Cognex), donepezil (Aricept), rivastigmine (Exelon) and galantamine (Razadyne, formerly called Reminyl).
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Cholinesterase inhibitors are not useful in dementia caused by Huntington's disease or traumatic brain injury.
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In animal tests Guilford's PARP inhibitors reduce stroke-induced brain damage by up to 70%.
Aromatase inhibitors, like Arimidex, stop estrogen production completely by curtailing a hormone called aromatase.
AstraZeneca itself is building an arsenal of anti-cancer pills known as tyrosine kinase inhibitors.
They are often used alongside angiotensin-converting enzyme inhibitors, such as Accupril, Zestril and Prinivil.
However, the protease inhibitors have been linked to skin rashes and heightened anemia in some patients.
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Inhibitors can prevent HIV from entering cells or block steps in the replication of the virus.
It is one of a class of drugs called selective serotonin reuptake inhibitors (SSRI).
Drugs included angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs) and diuretics, with NSAIDs.
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The only other frontline drugs are combinations which include protease inhibitors which are more difficult to take.
Protease inhibitors shut down AIDS enzymes by locking onto readily available toeholds, but hep-C's protease is smooth.
Celebrex is the first of a new kind of painkiller called COX-2 inhibitors to get FDA approval.
The factor 10a inhibitors have "home run potential, " says Citigroup analyst Matthew Dodds in a recent report.
"We really need to know whether cox-2 inhibitors are safe for patients with heart disease, " Nissen says.
But others, including Schering-Plough and Vertex Pharmaceuticals, prevailed and now have protease inhibitors in early human trials.
In 2000 Hazuda and her team published two landmark papers showing that integrase inhibitors could be made.
Inhibitors work by curbing the action of the angiotensin-converting enzyme (ACE), which governs the release of angiotensin-2.
The Cox-2 inhibitors were only cost-effective, the authors concluded, in patients who already had a history of ulcers.
Due out in 2004, it may work faster and longer and cause fewer ulcers than other COX-2 inhibitors.
Hassan has high hopes for two second-generation COX-2 inhibitors, valdecoxib and parecoxib, which are finishing up testing now.
Beyond treating arthritis, it was believed that the COX-2 inhibitors might have other medical benefits as well.
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Its biggest selling point: It does not seem to raise cholesterol as similar drugs, called protease inhibitors, do.
Donepezil is one of a class of drugs known as cholinesterase inhibitors while memantine is a glutamate moderator.
"Very senior management said I should stop working on integrase and start working on CCR5 inhibitors, " Hazuda says.
In recent years evidence has begun to implicate exposure to a class of chemicals known as acetylcholinesterase inhibitors.
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