Today, the only recognized limitations are that (1) Congress may not regulate non-economic behavior based solely on an attenuated link to interstate commerce, and (2) Congress may not regulate intrastate economic behavior if its aggregate impact on interstate commerce is negligible.
Perversely, the individual mandate compels individuals by law to purchase health insurance sold only within completely intrastate markets, a regulatory compulsion that by its very construction fails to involve the regulation of interstate commerce, which presumably authorizes it in the first instance.