Well, if--as with a real highway--it destroys something irreplaceable, a vital ecosystem essential to human life.
His death hits Makani hard because its founder is irreplaceable: a Stanford-trained engineer who pushed the edge of design, an able leader who snared funding from Google and the ARPA-E, and a handsome windsurfing champion who knew the power of the wind firsthand.
For social entrepreneurs, a strong network like Ashoka is an irreplaceable piece of a complicated puzzle.
More exactly, it is a form of relationship of immense and irreplaceable value to a few of the people we seek to help, and these few have their access severely curtailed by the use of visits to meet the needs of many, whose needs could be better met through other kinds of encounters.
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He was described as "an irreplaceable character" and a devoted Manchester United fan.
With these leavers goes a probably irreplaceable concentration of musical knowledge.
You do not possess the resources (or the social capital) I do to make enough money to support another, valuable, irreplaceable, one of a kind worker.
This heritage is an irreplaceable source of identity and a driver of future development and cohesion.
In my professional view, this transaction would deny the United States reliable and secure access to a vital - and, as a practical matter, irreplaceable - world-wide telecommunications infrastructure.
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And since Abbas has been deemed irreplaceable, the same West that turns a blind eye to his corruption, refuses to criticize his encouragement of terrorism.
The man is irreplaceable, but this marvellous book is a consolation.
"He's an iconic figure that everybody wants around, he's the world's greatest salesman and that's irreplaceable, " said Gene Munster, a senior research analyst at Piper Jaffray who has been covering Apple since 2003.
Before upgrading, I fully backed up the device to avoid the loss of irreplaceable media and keep my device from ending up a brick.
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The two men spent the better part of an hour trying to convince the crowd -and perhaps themselves- that the show is bigger than its cast and, as a result, no one judge is irreplaceable.
First, during the recession, the American worker received the loudest, most clear message in our country's history: No job is permanent, few employees are irreplaceable, and everyone should be prepared to look for a new job at a moment's notice.
These losses are irreplaceable, and weigh heavily in favor of declining to impose a stay or injunction.
Now survival is commonplace, and a large part of the credit goes to the irreplaceable component of medicine known as intensive care.
But this occurs only when the doctor's expertise is considered irreplaceable to the FDA. In at least one case, a panelist owning tens of thousands of dollars in one drug firm's stock was allowed to give advice about a competitor.
She said they came into her home "like a swarm of locusts" and moved valuables - including irreplaceable photo albums - out of reach of the floodwater.
But the Kurchatov's nest-egg will not last for ever nuclear reactors being what they are, it could last for a very short time indeed and it is irreplaceable, unless somebody else chooses to build nuclear reactors in the Moscow suburbs.
With the possible exceptions of Cano and Sabathia, not only is no Yankee irreplaceable, none even matter that much, unless they go missing for months at a time.
An estimated half a million books in the nation's libraries were damaged, along with irreplaceable archival documents and prints.
"I was afraid it would be bad for business that Morsi won, " said Ms. Matta, sporting half a shaved head, torn jeans, and a baggy T-shirt that read: 'In order to be irreplaceable one must always be different.
With Israel and the US lining up to support him after the Hamas victory, Abbas continued to turn a blind eye to his colleagues' criminality. his new status as the irreplaceable "moderate, " he allowed his advisers and colleagues to continue enriching themselves with the international donor funds that skyrocketed after Hamas's victory.
In a newspaper interview earlier on Wednesday, Mr Sarkozy said that Syria could "provide an irreplaceable contribution to solving Middle East issues".
Both Amazon and Apple were docked for how easy it was to modify an account over the phone -- and, in close succession, have both put at least a momentary lockdown on the changes that led to Honan losing much of his digital presence and some irreplaceable photos.
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What is most important to remember is that while a coach may excel at any number of these traits, history has shown that they certainly are not irreplaceable.
There's a constant hysteria in the land about threats to the Constitution, to religion, to strategic territory with irreplaceable sources of water or raw materials sold to secret American or Israeli companies.
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