The Welsh team were without half a dozen top players including James Collins and Craig Bellamy.
Skipper James Collins grabbed a brace of tries on the night, while Will Runciman slotted nine conversions.
And the problem was exacerbated when James Collins was carried off in Friday night's 25-19 win at Nottingham.
Wales were back on level terms thanks to James Collins as the defender turned in Aaron Ramsey's near-post corner.
Wales captain James Collins had a header cleared off the line while Rob Earnshaw saw a close-range shot saved.
"I don't think it represents the creation of an artificial life form, " said biomedical engineer James Collins at Boston University.
After Wales rode a tricky start, James Collins found space on the back post to side-foot home a Gareth Bale free-kick.
His chances of playing some part against Scotland have been boosted by the withdrawals of defenders James Collins and Chris Gunter.
James Collins seemed to pull down Jones as the Trinidad and Tobago striker attempted to get his head on a free-kick.
James Collins and Gabriel Agbonlahor each struck the United woodwork before Villa went ahead when Ashley Young scored from the penalty spot.
Toshack is without a host of players including Premier League quintet Craig Bellamy, James Collins, Jack Collison, Simon Davies and Boaz Myhill.
James Collins struggled to contain the aerial threat posed by 20-year-old Carroll but it was Owen who first threatened the Hammers goal.
"I would have thought there were better options within the squad, someone like Ashley Williams or James Collins, " Ratcliffe told BBC Wales.
The dominant James Collins twice had to clear yards from his own goalline, and then home captain Miroslav Klose sent a header wide.
Campbell did the rest, leaving Stephen Warnock and James Collins trailing in his wake before steering a calm finish around the advancing Friedel.
Houllier decided to leave out acting skipper and central defender Richard Dunne but his replacement, Carlos Cuellar, formed a solid partnership with James Collins.
BBC: Gerard Houllier 'relief' after Villa win over West Brom
Another Flood penalty kept Tigers in range, and a yellow card for Worcester flanker James Collins seemed to have given the visitors the edge.
United almost ended an enthralling first 45 minutes in the lead when Park struck a post after James Collins could only partially clear Valencia's cross.
"He is a nice lad but, as you know, we have four centre-backs in James Collins, Richard Dunne, Carlos Cuellar and Ciaran Clark, " said the Frenchman.
Gerard Houllier, whose Villa side needed an 89th-minute header from James Collins to beat Blackpool, said he would be "very disappointed" if the Seasiders were fined.
Doyle set it up with a superbly-weighted through pass and Keane, displaying typical coolness, outpaced James Collins before chipping the ball over the advancing keeper Wayne Hennessey.
The cash-strapped Championship club led twice through goals by Johnny Ertl and Darren Ambrose, but were pegged back first by James Collins and then, cruelly, by the Bulgarian.
With the hosts missing the experience of Craig Bellamy, Simon Davies, James Collins and Jason Koumas, manager John Toshack had little option but to put his faith in youth.
Bent's persistence created a chance but Green made a decent block at his near post and then Cole hacked away from his own line when James Collins headed towards goal.
Richard Dunne did brilliantly to deny the big Ivory Coast striker when he skipped inside James Collins and made for goal, but did rather less well from the resulting corner.
They trailed 2-1 at Upton Park after a pair of headed goals by James Collins, but the prolific Robin van Persie, on as a late substitute, equalized in injury time.
Porokara, on the edge of the "D", found Moisander free on the left to charge into the box, evade a challenge from James Collins and toe-poke home into the far corner.
Kuranyi was again denied as the half drew to a close when James Collins blocked his shot inside the box after Wales were again guilty of giving the ball away cheaply.
Referee Peter Walton pointed to the spot as Zhirkov went down under the challenge from James Collins as he raced into the area, leaving Lampard to thrash the penalty beyond Friedel.
Marlon Harewood and DJ Campbell both scored to cancel out goals from Stewart Downing and Nathan Delfouneso but Villa defender James Collins headed a late winner to deny the Seasiders at the death.
应用推荐