Negative briefing documents from FDA staff hardly represent a death knell for a drug.
What is a boon to us consumers is a death knell for computer companies.
"To this day, they've never been recovered, " Sesame Workshop President and CEO Gary Knell said.
He said the announcement was far from sounding the death knell for onshore wind.
Both Pittman and Knell arrive following a period of turmoil, as new CEOs often do.
The rise of the internet has long been seen as the death-knell for the middle-class musician.
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It is not clear to me that this would be a death knell for the industry.
The BBC's Yolande Knell says this trial could determine Mr Lieberman's future in politics.
And paying performance royalties is not going to be the death knell for terrestrial radio.
This could sound its death knell and help Mr Mugabe keep himself and his party afloat.
Few analysts think that this would sound the death-knell for other countries' economies and markets.
Liberals must overcome their fear that any change at all is the death knell for social insurance.
Now, with many banks still weakened by the financial crisis, the regulation could be a death knell.
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"People taking the law into their own hands is the death knell of the state, " he said.
If the world's biggest social network can't make HTML5 work, is this the death knell for the technology?
But if history is any indication, it's too early to sound the death knell on his political career.
But campaign group Bridgwater Forward said the arrival of Tesco would be the "death knell" for the town centre.
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At first, of course, the rediscovery of the Mendelian gene was thought to be the death knell for Darwinism.
For smaller companies interested in the Gulf, the rising production costs mean that the death knell has been sounded.
The Fitch credit agency has taken away its triple-A rating, a veritable death knell for a bond insurer.
Save Trafford General's Matthew Finnegan said their closure would "sound the death knell" for the future of the hospital.
Their fear is that the Web is sounding the death knell for traditional advertising channels like newspapers, television and magazines.
Considering that Apple derives over 70% of its profits from iPhones, such a scenario will be a virtual death knell.
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The death knell for the junta came following the disastrous 1982 invasion of the U.K.-controlled Falkland Islands in the South Atlantic.
Cisco is spending "millions of dollars" on the academy program, says Scott Knell, Cisco's higher-education marketing manager in Santa Clara, Calif.
For would-be sellers of distance learning, the news may be death knell.
This is firstly something of a death knell for organic farming: we know that that is more land hungry than conventional farming.
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Despite the death knell sounded throughout the media, most people and most banks did not encumber themselves with mountains of unsecured debt.
The losses are what ultimately led to the death knell for ChampionsWorld.
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As the search for any remaining gunmen continues, Egypt has closed its Rafah border crossing with Gaza, our Cairo correspondent Yolande Knell reports.
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