Early tests suggest 2-heptanone may also find a role in humans as a local anaesthetic.
In many cases a local anaesthetic was applied before the limb was removed with simple surgical instruments.
Mrs Cannon, a great-grandmother from Wavertree, Liverpool, has had two courses of RFA under a local anaesthetic.
Among other treatments, doctors can block nerve transmission with local anaesthetic can also help disturb pain messages.
It can be corrected with surgery that can be done as a day case, under local anaesthetic and sedation.
Morphine will be replaced with a local anaesthetic stored in a small gadget.
If the drug is deemed suitable it is injected into the muscle while the patient is sedated or under local anaesthetic.
Local dealers then cut it with other chemicals such as benzocaine, a local anaesthetic which simulates the numbing effect that real cocaine has on the gums.
But a British expert said that while giving only a local anaesthetic for such a major operation had advantages, it also involved extra risks for the patient.
If thawed semen is used, it has to be injected directly into the uterus through the ewe's belly wall, which requires a local anaesthetic and also large quantities of defrosted semen.
One of the human volunteers was examined after inhaling 0.0035 ounces (100 milligrams) of cocaine, "a drug routinely used in ear, nose, and throat medicine as a local anaesthetic and vasoconstrictor, " the researchers write in the British Medical Journal this week.
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