The solution sometimes is mixed with other medications, such as a local anesthetic.

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They randomly assigned patients to get either vertebroplasty or a fake procedure in which patients were injected with local anesthetic but no cement.

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It requires a local anesthetic and I'd say mild sedation.

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Previous work at Queen's University found that prawns show prolonged rubbing when an antenna was treated with weak acetic acid but this rubbing was reduced by local anesthetic.

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