In smaller studies, Benlysta had failed to provide a benefit across all patients with lupus.
Wall Street expected a lupus drug Glaxo was developing with Human Genome Sciences to fail.
Two clinical studies involving 1, 684 patients with lupus demonstrated the safety and effectiveness of Benlysta.
FORBES: Human Genome Sciences' Benlysta Approved To Treat Lupus
Prior to Benlysta, FDA last approved drugs to treat lupus, Plaquenil (hydroxychloroquine) and corticosteroids, in 1955.
FORBES: Human Genome Sciences' Benlysta Approved To Treat Lupus
But Smith figured excess TNF might cause autoimmune diseases such as rheumatoid arthritis or lupus.
Hani Abou El Kheir, 16, was attacked in Lupus Street, Pimlico, on 27 January.
Certain conditions such as rheumatoid arthritis and lupus are also associated with enlarged nodes.
Adding to the uncertainty: Lupus is a notoriously slippery disease, with highly unpredictable symptoms, making trials difficult.
Drugs targeting them may one day treat diseases as diverse as psoriasis, multiple sclerosis, lupus, even cancer.
Hundreds of people streamed through the entrance to the site in Lupus Street, Pimlico, on Sunday morning.
There is a lot of variability and patients don't uniformly show symptoms of the onset of lupus.
He's followed by a rapidly depleting line of the walking wounded, and a posse of salivating lupus.
Along with the lupus drug, it is one of the first drugs to emerge from Glaxo's gene-hunting efforts.
The gene-hunting found hundreds of new targets, yet drugs like the lupus medicine are only now beginning to emerge.
Hani Abou El Kheir, 16, was killed in a suspected drugs-related attack in Lupus Street, Pimlico, on 27 January.
Glaxo's first big success may come early next year, if its new lupus drug, Benlysta, is approved by regulators.
Estimates vary on the number of lupus sufferers in the United States ranging from approximately 300, 000 to 1.5 million people.
FORBES: Human Genome Sciences' Benlysta Approved To Treat Lupus
Hani Abou El Kheir died from multiple stab wounds in a suspected drugs-related attack in Lupus Street, Pimlico, last Sunday.
In lupus the body's immune system turns on itself and produces "autoantibodies" that attack the joints, skin, kidneys, heart and brain.
Another promising treatment: an anti-CD20 antibody--kind of a second-generation Rituxan--that Genentech plans to test against rheumatoid arthritis, lupus and multiple sclerosis.
Hani Abou El Kheir, 16, died from multiple stab wounds in a suspected drugs-related attack in Lupus Street, Pimlico, on Sunday.
"This is the most exciting thing that has come along in my career, " says USC's Stohl, who has studied lupus since 1982.
Hani Abou El Kheir, 16, was stabbed in Lupus Street, Pimlico, just before 19:00 GMT on Sunday in a suspected drugs-related attack.
HGS' best shot at a breakthrough is a new drug that targets lupus, the auto-immune disease that afflicts half a million Americans.
Lupus is a serious, potentially fatal, autoimmune disease that attacks healthy tissues.
FORBES: Human Genome Sciences' Benlysta Approved To Treat Lupus
It has also improved the lot of those afflicted with multiple myeloma, another cancer, and a variety of autoimmune disorders including lupus.
Lupus is ten times more common in women and four times more likely to occur in Afro-Caribbean and Asian people than whites.
It's said that Canis lupus familiaris is Homo sapiens' best friend, but it's a relationship in which the dog has the upper paw.
But pretty much all the gain is due to the success in large trials last year with its new lupus drug Benlysta.
Police were called to Lupus Street, near where Hani lived on the Churchill Gardens estate, where the teenager was found with stab wounds.
应用推荐