Patients with the lymphocyte depletion subtype usually present with involvement of abdominal lymph nodes.

CNN: What is Hodgkin lymphoma's effect on the lymphatic system?

Most patients with nodular lymphocyte-predominant Hodgkin lymphoma present with localized disease in the upper neck.

CNN: What is Hodgkin lymphoma's effect on the lymphatic system?

Patients with mixed cellularity or lymphocyte deplete subtypes of HL often have HL involving the liver.

CNN: What is Hodgkin lymphoma's effect on the lymphatic system?

Both drugs turn off a natural brake on immune system activity called CTLA4 (cytotoxic T-lymphocyte antigen 4).

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And the lymphocyte deplete subtype is the kind that most often extends from nodes to adjacent organs.

CNN: What is Hodgkin lymphoma's effect on the lymphatic system?

But, perhaps surprisingly, only one of these differences, that in physical activity, proved to have a significant relationship with lymphocyte production.

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Its role in lymphocyte signaling was characterized and explored through lots of cell-based and in vivo models, including RNAi and other target validation approaches.

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He dubbed the protein B-lymphocyte stimulator, or BLYS ("bliss").

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Pfizer's drug tremelimumab and Bristol-Myers Squibb's ipilimumab are antibodies to a protein called CTLA-4 (cytotoxic T-lymphocyte antigen-4) that acts as an emergency brake to prevent killer T cells from attacking healthy tissue.

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Benlysta is delivered directly into a vein (intravenous infusion) and is the first inhibitor designed to target B-lymphocyte stimulator (BLyS) protein, which may reduce the number of abnormal B cells thought to be a problem in lupus.

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