While Microsoft typically works with handset makers, Yahoo!

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Mr. Briggs, who has worked for GM in the past and now works with other auto makers including Honda Motor Co.

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The standards-based approach to school reform begins by looking at the goals that policy makers seek to accomplish and then works backward to design ways of reaching these goals.

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Narayen notes that Adobe works happily with some 70 makers of phones, tablets and set-top boxes.

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Express Scripts is a pharmacy benefit manager, or PBM, that works as a middleman between drug-makers and employers when it comes to buying drugs.

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"The shocking thing is that Pfizer didn't know about this effect ahead of time, " says James Stein, a cardiologist at the University of Wisconsin who works with Merck, Pfizer and other drug makers.

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Renert says Tello works with products from Cisco Systems and Avaya, makers of traditional private branch exchanges (PBXs), plus Digium, an open-source PBX software company.

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The problem is that the human gamble only works if there is a record of experimental outcomes and if decision makers consult that record.

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While Winfrey works on her new network, other up-and-coming money makers have a chance to push her off of her throne.

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