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Tries from Will Harries and Matthew Watkins helped the Dragons into a healthy 21-10 first-half lead.
BBC: Dragons 28-20 Ospreys
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And Lesley Vainikolo and Wales' Matthew Watkins each scored two tries after the break to seal the bonus point.
BBC: Gloucester 48-5 Calvisano
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The wing romped over from 30 yards and Matthew Watkins slotted the conversion, showing the returning Bowen how it should be done.
BBC: Scarlets wing Tal Selley leaves Kenny Logan sprawling
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James captains the side from outside centre, a position vacated by Matthew Watkins who will now be favourite for the Wales number 13 jersey.
BBC: Saturday, 28 January
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The Dragons brought on Matthew Watkins for his debut, the Wales and former Scarlets three-quarter having been kept out by a series of injuries since his summer move from Gloucester.
BBC: Scarlets 18-3 Dragons
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Jon Davies got the Llanelli-based region moving, though, freeing Andy Fenby who crossed the line but was denied a try when a superb Matthew Watkins tackle knocked the ball from his grasp.
BBC: Dragons 9-14 Scarlets
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Just before the break the Scarlets looked to have got back into the game but Bristol centre Rob Higgitt superbly tackled Matthew J Watkins with the try line at his mercy.
BBC: Bristol 18-11 Scarlets