In addition, results presented last year for our monoclonal antibody solanezumab support the amyloid hypothesis.
It is a human monoclonal antibody that attacks the toxins anthrax bacteria spew out.
ImClone's Erbitux blocked the EGF receptor in a slightly different way, using an injectable monoclonal antibody.
Monoclonal antibodies are engineered versions of natural immune-system fighters that attack a particular target.
By 1993 the company had designed a monoclonal antibody to VEGF that slowed tumor growth in animals.
Instead, it focused on treating cancer with monoclonal antibodies, an approach that was highly unpopular at the time.
Genentech unit is looking into another monoclonal antibody called crenezumab that also targets plaque buildup in the brain.
Among the furthest along in the pipeline is a monoclonal antibody called elotuzumab from Bristol-Myers Squibb Co.
This was controversial at first, but Slamon persuaded Genentech to test a monoclonal antibody that would block this protein.
Both drugs are monoclonal antibodies that are supposed to attach to the amyloid protein and clear it from the brain.
So far Innogene has produced TherCIM, a monoclonal antibody for targeted cancer therapy that is already marketed in Southeast Asia.
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This, she adds, should be put into context: the development of bone-marrow transplantation or monoclonal-antibody treatments both took several decades.
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This follows on the heels of Pfizer out-licensing another oncology drug, CP-870-893, an anti-CD40 monoclonal antibody, to VLST Corporation.
That's when UCSD oncologist Ivor Royston and research assistant Howard Birndorf founded Hybritech to explore using monoclonal antibodies to fight cancer.
Bigner spent years trying to make monoclonal antibodies against the mutant protein.
Novartis hooked up with Schwab and has crafted monoclonal antibodies to Nogo.
For example, monoclonal antibodies target and kill tumors while sparing healthy cells.
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Today monoclonal antibodies are used to treat rheumatoid arthritis, transplant rejection, psoriasis, Crohn's disease, multiple sclerosis, macular degeneration and several types of cancer.
Unlike chemotherapy, which uses chemicals to poison cancer cells, Rituxan's monoclonal antibody kills tumor cells much as the body's own antibodies kill invading germs.
None of the majors are willing to invest big, the way that Roche did with Genentech decades ago when monoclonal antibodies were still controversial.
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She said using antibodies as 'magic bullets' had been clinically difficult, and the mTCRs were difficult to make and had all the same problems as monoclonal antibodies.
After years of work monoclonal antibody therapies eventually became blockbuster products.
Lucentis, approved in June for wet AMD, is essentially a fragment of the monoclonal antibody that was used to make the company's colon cancer drug Avastin.
Xolair is a biological compound, called a monoclonal antibody, that attaches itself to immunoglobin E, one of the body's defensive weapons that goes into overdrive in allergy patients.
Developed using technology from partner Seattle Genetics, the drug is a monoclonal antibody containing a toxic chemotherapy that attacks cancer cells if they express glycoprotein NMB, or GPNMB.
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Tysabri, by contrast, will probably never face true generic competition, because it is a type of drug called a monoclonal antibody that will be much harder to produce cheaply.
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Xolair is a monoclonal antibody to IgE that works like a Star Wars missile defense for allergies, binding to and inactivating excess IgE before it can trigger an attack.
Stem cell therapies have the potential to surpass monoclonal antibodies because they use cells doing what cells normally do to stimulate the body to do what it normally does.
The most successful offspring is Idec Pharmaceuticals (nasdaq: IDPH - news - people ), which, with help from Genentech, developed Rituxan, a monoclonal antibody for non-Hodgkin's lymphoma.
Other notes: CDX-011 is a monoclonal antibody drug conjugate.
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