In addition, results presented last year for our monoclonal antibody solanezumab support the amyloid hypothesis.
It is a human monoclonal antibody that attacks the toxins anthrax bacteria spew out.
ImClone's Erbitux blocked the EGF receptor in a slightly different way, using an injectable monoclonal antibody.
By 1993 the company had designed a monoclonal antibody to VEGF that slowed tumor growth in animals.
Genentech unit is looking into another monoclonal antibody called crenezumab that also targets plaque buildup in the brain.
Among the furthest along in the pipeline is a monoclonal antibody called elotuzumab from Bristol-Myers Squibb Co.
This was controversial at first, but Slamon persuaded Genentech to test a monoclonal antibody that would block this protein.
So far Innogene has produced TherCIM, a monoclonal antibody for targeted cancer therapy that is already marketed in Southeast Asia.
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This follows on the heels of Pfizer out-licensing another oncology drug, CP-870-893, an anti-CD40 monoclonal antibody, to VLST Corporation.
Unlike chemotherapy, which uses chemicals to poison cancer cells, Rituxan's monoclonal antibody kills tumor cells much as the body's own antibodies kill invading germs.
After years of work monoclonal antibody therapies eventually became blockbuster products.
Lucentis, approved in June for wet AMD, is essentially a fragment of the monoclonal antibody that was used to make the company's colon cancer drug Avastin.
Xolair is a biological compound, called a monoclonal antibody, that attaches itself to immunoglobin E, one of the body's defensive weapons that goes into overdrive in allergy patients.
Developed using technology from partner Seattle Genetics, the drug is a monoclonal antibody containing a toxic chemotherapy that attacks cancer cells if they express glycoprotein NMB, or GPNMB.
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Tysabri, by contrast, will probably never face true generic competition, because it is a type of drug called a monoclonal antibody that will be much harder to produce cheaply.
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Xolair is a monoclonal antibody to IgE that works like a Star Wars missile defense for allergies, binding to and inactivating excess IgE before it can trigger an attack.
The most successful offspring is Idec Pharmaceuticals (nasdaq: IDPH - news - people ), which, with help from Genentech, developed Rituxan, a monoclonal antibody for non-Hodgkin's lymphoma.
Other notes: CDX-011 is a monoclonal antibody drug conjugate.
The day before the opening today of the ASH conference in Atlanta, TG Therapeitics announced it has initiated a phase 1 and 2 clinical trials to evaluate the safety, tolerability and efficacy of its product, TG-1101, a novel third-generation anti-CD20 monoclonal antibody, in combination with Revilimid for patients with relapsed or refractory B-cell lymphoid malignancies who were previously treated with anti-CD20 antibody therapy.
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This, she adds, should be put into context: the development of bone-marrow transplantation or monoclonal-antibody treatments both took several decades.
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