All were aged 2 to 14 years and were suffering from advanced, or persistent, neuroblastoma.
The family raised the money with the help of the Neuroblastoma Children's Cancer Alliance.
The couple also hope that more people will become aware of neuroblastoma through Lily-Mae's story.
In the UK, 486 cases of neuroblastoma have been diagnosed in the last five years.
Oscar Knox was diagnosed with neuroblastoma - a rare cancer which mainly affects children - in November.
Lewis Mighty was diagnosed with neuroblastoma in 2008, a childhood cancer which attacks the sympathetic nervous system.
The four-year-old from Galway in the Irish Republic has been diagnosed with high-risk neuroblastoma, a rare children's cancer.
BBC: Lily-Mae: Charity single tops Irish chart for second week
One parent of a child who had been blinded by neuroblastoma at 18 months old welcomed the news.
Sophie was diagnosed with neuroblastoma, which accounts for about one in six cancer deaths in children, in February.
Any money raised from the single will be split between the Sunni Mae Trust and the Neuroblastoma Society.
Four-year-old Oscar Knox, who was diagnosed with high risk neuroblastoma, will begin his specialist treatment in the US on Monday.
His family set up a website charting Alexander's battle against the illness and to raise funds for research into neuroblastoma.
It works by hunting down neuroblastoma cells that have survived conventional treatment and attaching antibodies to specific molecules on their surface.
Seven-year-old Alexander Strong from Epworth died last month from neuroblastoma, which affects fewer than 100 children in the UK every year.
She was treated for neuroblastoma one of the most common cancers among young infants - at Queen's Medical Centre, Nottingham in 1999.
According to Cancerbacup, some 100 children develop neuroblastoma and around 60 children develop osteosarcomas or Ewing's sarcoma in the UK each year.
Neuroblastoma is a cancer of specialised nerve cells, called neural crest cells.
Lily-Mae Morrison, from County Galway, has been diagnosed with high risk neuroblastoma.
About 100 children in the UK are diagnosed with neuroblastoma every year, with the average age for diagnosis of those affected being two-years-old.
The pop mogul has agreed to pay an undisclosed sum to allow two-year-old Sophie Atay, from Birtley, to receive treatment for stage 4 neuroblastoma.
Her 3-year-old son, Liam, had just been diagnosed with a neuroblastoma.
Reviewing the research for the Lancet, Professor William Woods, a US expert, said that no link between neuroblastoma death rates and less rigorous child health examinations had been proved.
This trial will be open to high-risk neuroblastoma patients who are nine months from diagnosis and within four months of the last round of aggressive treatment to control the tumour.
"We were devastated to hear that Louis had neuroblastoma, and finding out that he had been blinded by the disease was really hard to deal with, " said Michael Moorhouse, from Bradford.
Since being diagnosed with neuroblastoma - a cancer of the nerve cells - Belle has been undergoing treatment at the Royal Marsden Hospital in Sutton as part of a clinical trial.
Neuroblastoma accounts for around 7% of all childhood cancers.
Other neuroblastoma families being treated at Great Ormond Street have said they are so frightened by the "lottery" they have started raising funds before the child is officially recommended to try the therapy, just in case.
Late in the summer ten kids with advanced neuroblastoma, one of the deadliest childhood cancers, began undergoing a radical new gene therapy with a breathtaking goal--to fight the disease not by deploying often inadequate chemotherapy and radiation but by jiggering the immune system to attack tumors it otherwise ignores.
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