British Transport Police (BTP) said no train passengers were hurt and the train was not derailed.
BBC: Train hits car on Great Coates level crossing killing two
No train passengers were hurt and the service was not derailed during the crash, which happened at about 19:40 BST.
BBC: Scene of the crash in Great Coates
"This was not because of any lack of integrity of the bridge in southeast Missouri, but because of a train that derailed and had a bunch of rail cars slamming around, " he said.
WSJ: Mo. highway buckles after rail cars hit overpass
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