When injected with the protein leptin, which the obese gene codes for, they shed up to one-third of their weight in fat.
FORBES: Hunger Pangs
In 1994 a scientist at Rockefeller University discovered the "obese" gene, which plays a role in regulating hunger.
And, while rates of obesity dropped substantially between first and second degree relatives of obese patients without the gene mutations, this was far less obvious among relatives of those who were carriers.
BBC: NEWS | Health | Faulty gene link to obesity risk
Mice missing the gene were obese.
The German researchers examined the body weights and DNA of 181 relatives of 25 extremely obese patients who carried the gene mutation.
Millennium scientists started by discovering a gene that is expressed more often in obese people than lean ones.
FORBES: Magazine Article
The problem is that obese humans very rarely show a mutation in either the gene for leptin or that for its receptor.
ECONOMIST: Obesity
Thinner volunteers were found to be more likely to carry the protective form of the gene, while the other version was more common in obese people.
BBC: NEWS | Health | Gene that makes you eat too much
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