In the long run, solving the challenges that the Summit laid out (PK, permeability, oral bioavailability, and binding modes) will be key to this class delivering the big therapeutic impact we all hope to witness.

FORBES: Innovation Snapshot: Macrocyclic drugs to unlock new therapeutic targets

This low oral bioavailability shows that in the monkey model, pregnancy does not alter the substantial metabolism to inactive conjugates that occurs in the GI tract and liver after oral ingestion and limits internal exposures to BPA and when compared with injections.

FORBES: Leading Environmental Group Scientist Praises FDA's Ground-Breaking Research On BPA: A Tipping Point In The Controversy?