"The devastating conditions suffered by the Bangladeshi refugees as they fled the war with Pakistan offered ORT (oral rehydration therapy) its definitive test, " according to an August 2003 paper published in the journal Clinical Infectious Diseases.
Because of the high risk of oral clefts in fetuses exposed to topiramate, women should have a negative pregnancy test before starting Qsymia and every month while taking the drug, in addition to using contraception.