The event saw Oscar-winning actor and Grammy-winning artist Jamie Foxx receive the MTV Generation Award, the show's version of a lifetime achievement trophy.
Caine has been widely praised for a performance which has brought the Oscar-winning actor - who will turn 70 next year - another Academy Award nomination.
The Oscar-winning director picked up the outstanding British film award, for Bond's 23rd outing, alongside producers Michael G Wilson and Barbara Broccoli at this year's Baftas.
Michael Westmore, the legendary Hollywood makeup artist best known for his 18 years of Emmy award-winning work across the Star Trek series, as well as for winning the Oscar for the movie Mask, joins the show as a mentor to the contestants.