Avandia works by hitting a drug target called the peroxisome proliferator-activated receptor (PPAR) gamma.

FORBES: Open-Source Drug Safety?

They take aim at one or more of three emerging targets: These are peroxisome proliferator-activated receptors (PPARs), which are akin to master relay switches that control how the body uses sugar and fat.

FORBES: Silencing "Syndrome X"