Roche also presented positive results for its hepatitis C polymerase inhibitor at the Boston meeting.
The polymerase helps the virus churn out millions of copies of its RNA genetic material.
But what does the promoter have to be like for the polymerase to find it?
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The fifth was in the polymerase 2, a protein that helps the virus replicate its genetic material.
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To see how the polymerase seeks out the promoter, Dr Bustamante and his colleagues played a cruel trick.
ECONOMIST: How (and why) to find a needle in a haystack | The
Doctors hope, ultimately, to boost cure rates by combining protease inhibitors with a second drug class called polymerase inhibitors.
Ms. Dewey-Hagborg amplifies small DNA strands using a technique called PCR polymerase chain reaction.
Three other companies that Jenner and Markowitz own are working on a different class of enzyme-attacking drugs called polymerase inhibitors.
Idenix Pharmaceuticals (nasdaq: IDIX - news - people ) partnered with Novartis on its polymerase inhibitor, nm283.
The virus' genetic code was uncovered with one of the most common tests in biology, the polymerase chain reaction, or PCR.
Real-Time Polymerase Chain Reaction (RT-PCR) uses nanoscaled fluorescent probes that allow the tracking of the progress of the amplification from the start.
Much attention is being lavished on two classes of enzymes inside hepatitis C that are crucial for its replication: polymerase and protease.
The bee-research team went on to confirm via polymerase chain reaction that hives with colony collapse disorder were far more likely to have IAPV.
Roche (other-otc: RHHBY - news - people ) also presented positive results for its hepatitis C polymerase inhibitor at the Boston meeting.
These chemicals may speed one of the most fundamental reactions in genetic research, called polymerase chain reaction (PCR), by allowing scientists to perform it at higher temperatures.
For years, he had been making the case that polymerase chain reaction (PCR) would be the best way to test for the existence of Earth-like DNA on Mars.
Idenix Pharmaceuticals partnered with Novartis on its polymerase inhibitor, nm283.
Roche, which already sells pegylated interferon (Pegasys) and ribavirin (Copegus), announced in May that in a small early-stage trial its polymerase inhibitor was effective in significantly reducing the viral load.
In August ViroPharma of Exton, Pa. said data from an early-stage trial of its polymerase inhibitor reduced the virus 99% on average after 14 days of treatment in combination with interferon.
Roche, Idenix Pharmaceuticals and others are chasing polymerase inhibitors.
One example is the polymerase chain reaction (PCR), a standard technique which employs enzymes to churn out millions of copies of a DNA sequence and involves cycles of gentle heating and cooling.
By blocking these errant molecules, D-serine and poly ADP-ribose polymerase (PARP), researchers may be able to stop brain cells from dying while avoiding the toxic side effects that have plagued previous experimental treatments.
By blocking these errant molecules, called D-serine and poly ADP-ribose polymerase, known as PARP, researchers may be able to stop brain cells from dying, while avoiding the toxic side effects that have plagued previous experimental treatments.
Current detection tools using nanotechnology allow high-speed molecular detection of pathogens through analysis of their DNA in a matter of a few minutes where classical detection tools using regular PCR (polymerase chain reaction) would take over six hours.
The polymerase chain reaction (PCR) is a scientific technique in molecular biology to amplify a single or a few copies of a piece of DNA across several orders of magnitude, generating thousands to millions of copies of a particular DNA sequence.
In August ViroPharma (nasdaq: VPHM - news - people ) of Exton, Pa. said data from an early-stage trial of its polymerase inhibitor reduced the virus 99% on average after 14 days of treatment in combination with interferon.
Gleason also cites a new class of drugs known as PARP (poly ADP-ribose polymerase) inhibitors, which appear to be highly effective in treating breast cancer patients with certain mutations, and finally the sale of new products that could earn new markets.
It was a stretch of DNA that could be transcribed by an enzyme called polymerase into a chemically similar molecule known as RNA. The RNA acted as a messenger that was itself translated into protein molecules in sub-cellular factories called ribosomes.
ECONOMIST: Genomics has not yet delivered the drugs, but it will
In particular, this sensitivity makes the new chips better at searching for strands of DNA. At the moment, such searches require the number of DNA molecules in a sample to be multiplied using a trick called the polymerase chain reaction before there is a decent chance of detecting the target.
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