It is impossible for the species to be a viable population by natural reproduction.

BBC: Earth News - Giant fish 'verges on extinction'

Perhaps more technically, the family lines that focused on something other than reproduction died out as a fraction of the population.

FORBES: Lemin Wu, Economic Growth and Why Humanity Can't Have Nice Things

The rapid reproduction of bacteria means there is always a chance that a population of microbes will develop which is antibiotic resistant.

BBC: Animals and antibiotics: the risks