Someday he envisions cancer centers storing giant banks of premade T cells to match the patients' bone marrow and tumor types.

FORBES: Do-It-Yourselfer

Drinkers grew to like the blended flavor the slight tang and rich color of the old, the effervescence of the new and so enterprising brewers started selling premade "half-and-half" blends.

WSJ: Porters Get Fresh | Half Full

Then there are more existential threats, like a digital generation that favors 99-cent iPad apps over traditional toys, a shrinking number of toy stores and the looming concern that DIY 3-D printing will render premade plastic toys obsolete.

FORBES: Life After Barbie: Why Mattel Isn't Scared Of iPads And Video Games