The companies decided to end the program for developing the compound, called Dimebon, after it failed to meet two primary endpoints in a phase 3 trial studying its use with the existing treatment Aricept in patients with mild-to-moderate Alzheimer's.
WSJ: Medivation, Pfizer Alzheimer's Drug Fails to Meet Study Goals
X1 currently is in a research and development phase, where the primary focus is development, evaluation and improvement of the technology.
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Then, in 2010, Pfizer and Medivation announced that Dimebon failed to meet its primary and secondary goals in a phase 3 trial studying the drug's use by itself against placebo among mild-to-moderate Alzheimer's patients.
WSJ: Medivation, Pfizer Alzheimer's Drug Fails to Meet Study Goals
Teachers at a Cornish primary school have walked out in the second phase of a seven-day strike.
On Wednesday, the king told Mr Ensour that the "primary responsibility of this government in this transitional phase is to pave the way for a qualitative leap in Jordan's political history and democratisation".
The programme starts with an initial phase lasting six and eight months for primary and secondary education, respectively.
Primary end-points are needed for definitive (Phase 3) proof of efficacy, but they are the most pernicious concept in early stage development.
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The drugmakers reported that their bapineuzumab compound failed to meet two primary endpoints and, consequently, they decided to discontinue additional Phase III research planned, although follow-up evaluations and final data analyses will be conducted ( back story).
In the second phase, UNESCO reviewed and printed 9 million copies of primary and secondary school textbooks, which benefited 6 million students throughout Iraq for the academic year 2005-2006.
United Therapeutics Corporation ( UTHR) said today its Phase 3 trial of oral treprostinil, did not meet its primary endpoint.
FORBES: Pharma News: United Therapeutics, Zogenix, Par Pharmaceuticals
In the second phase, on-balance-volume and relative performance analysis play a primary role, though other technical tools are often also used.
The play-based Foundation Phase for three to seven-year-olds was due to be used in primary schools across Wales from September.
Also today, Trius Therapeutics (TSRX) said a phase 3 trial of its tedizolid phosphate treatment for bacterial skin and skin structure infections met its primary endpoint.
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