It's apparent from first glance that the Sabertooth is intended as such, given the six extra (programmable) buttons found on the shoulders and back of the controller, and the tiny OLED screen found along the bottom (allowing for the programming of said buttons).
And the true train and public transit buffs won't shy away from the RailDriver train controller, complete with a throttle, break, reverser, switch controls and 35 programmable buttons.