• Vertex is completing midstage testing of its drug telaprevir, a hepatitis C protease inhibitor.

    FORBES: Vertex's Lead Narrows

  • He designed early protease inhibitor drugs for AIDS, but the lead molecule failed in trials.

    FORBES: The Chemical Cobbler

  • However, the protease inhibitors have been linked to skin rashes and heightened anemia in some patients.

    WSJ: Hepatitis C Dilemma: Treat Illness With Interferon Now or Wait?

  • Vertex's stock sank 13% on Oct. 18 when Schering-Plough touted promising results for its rival protease inhibitor.

    FORBES: Magazine Article

  • The only other frontline drugs are combinations which include protease inhibitors which are more difficult to take.

    BBC: Aids drug hailed as 'major advance'

  • Schering is in discovery stages for a protease inhibitor that they hope to offer in pill form.

    FORBES: The Next HIV?

  • Protease inhibitors shut down AIDS enzymes by locking onto readily available toeholds, but hep-C's protease is smooth.

    FORBES: The Next HIV?

  • But others, including Schering-Plough and Vertex Pharmaceuticals, prevailed and now have protease inhibitors in early human trials.

    FORBES: Magazine Article

  • The protease works as a molecular scissors to cut out proteins that then form new viral particles.

    FORBES: Magazine Article

  • It took two years to get a stable, crystalline form of the hepatitis C protease enzyme for study.

    FORBES: Magazine Article

  • Its biggest selling point: It does not seem to raise cholesterol as similar drugs, called protease inhibitors, do.

    FORBES: Magazine Article

  • Doctors hope, ultimately, to boost cure rates by combining protease inhibitors with a second drug class called polymerase inhibitors.

    FORBES: Magazine Article

  • Jenner and Markowitz are watching Schering-Plough's development of a protease inhibitor, as well.

    FORBES: Magazine Article

  • However, as often happens, evolution has got to work and generated drug-resistant strains of the virus by modifying its protease.

    ECONOMIST: Drug testing

  • The drugs, so-called hepatitis C protease inhibitors, represent the first class of agents that directly target the hepatitis C virus.

    FORBES: Vertex Edges Merck In First Round of Hepatitis C Fight

  • Gilead is also testing a protease inhibitor for hepatitis C, a disease for which there aren't a lot of great treatments.

    FORBES: Gilead's Half-Empty Pipeline

  • Once this was done, "it became clear what a remarkable challenge" designing a protease inhibitor would be, says Vertex executive John Thomson.

    FORBES: Magazine Article

  • The leader in the pack with protease inhibitors for the hepatitis virus, say Markowitz and Jenner, is Vertex Pharmaceuticals of Cambridge, Mass.

    FORBES: Magazine Article

  • Much attention is being lavished on two classes of enzymes inside hepatitis C that are crucial for its replication: polymerase and protease.

    FORBES: Magazine Article

  • The surface of the hepatitis C protease turned out to be flat.

    FORBES: Magazine Article

  • One reason is that the flat geometry of the hepatitis C protease protein made it is difficult target to hit with small-chemical drugs.

    FORBES: Why Aren't There AIDS-Style Cocktails for Hepatitis C?

  • "This has got the potential to be the best in class protease inhibitor for HIV and AIDS, " says Palmer, the chief scientific officer.

    FORBES: Magazine Article

  • Data from a small, midstage clinical trial with its protease inhibitor, known as vx-950 or telaprevir, were "nothing short of spectacular, " says Markowitz.

    FORBES: Magazine Article

  • It was the first to market a protease inhibitor for AIDS in the U.S., but competing medicines ended up dominating the U.S. market.

    FORBES: Back From the Morgue

  • Telaprevir is a protease inhibitor that attacks the virus directly and blocks its replication, much the way antiretrovirals revolutionized the treatment of AIDS over a decade ago.

    FORBES: Magazine Article

  • Vertex's stock sank 13% on Oct. 18 when Schering-Plough (nyse: SGP - news - people ) touted promising results for its rival protease inhibitor.

    FORBES: Viral Vertigo

  • Thus far the most promising new class of such enzyme-attacking drugs looks to be protease inhibitors, best known for combating the progress of HIV infections in the body.

    FORBES: Magazine Article

  • Vertex also is in late-stage tests of a new AIDS drug, a protease inhibitor that requires only two pills a day versus six or more for rival remedies.

    FORBES: Machine Gunner

  • In 2011, Foldit players needed only 10 days to produce an accurate 3-D model of the Mason-Pfizer monkey virus, a protease whose structure had stumped scientists for 15 years.

    CNN: People and computers need each other

  • The agency says some drugs should never be taken with Mevacor including protease inhibitors, a class of HIV drugs and certain drugs used to treat bacterial and fungal infections.

    CNN: Statin labels will come with new safety warnings

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