The suits alleging primary pulmonary hypertension (PPH), a nearly always fatal condition, are the most valuable--the kind Fleming wants to tee up for trial.
One area where this is painfully evident is infusion pump therapy which is often used in cancer treatment, pain management, pulmonary hypertension and diabetes.
Some conditions associated with congenital heart defects, such as pulmonary hypertension, come with a mortality rate for the mother or infant as high as 50%, Dr. Franklin says.
Actelion Pharmaceuticals, best known for its pulmonary hypertension drugs.
FORBES: Actelion Executive To Head American College of Cardiology
In 2004, Cochran developed primary pulmonary hypertension (PPH).
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The closest thing to a real success, a two-drug combination known as fen-phen, helped people lose as much as 30 pounds a year by making them feel satiated, but it caused heart valve problems in some and pulmonary hypertension in others.
Some research associates use of citalopram, fluoxetine and sertraline with a rare but serious newborn lung problem (persistent pulmonary hypertension of the newborn, or PPHN) when taken during the last half of pregnancy, as well as heart defects affecting the septum the wall of tissue that separates the left side of the heart from the right side of the heart.
The drug is already approved to treat pulmonary arterial hypertension via other delivery methods.
FORBES: Pharma News: United Therapeutics, Zogenix, Par Pharmaceuticals
The company has tried to create new enthusiasm with with efforts to expand into hepatitis C, the viral liver disease that is looking like the next big drug market, and into other areas such as heart disease, cystic fibrosis, and pulmonary arterial hypertension.
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The study of a sustained release oral formulation of the synthetic form of prostacylin showed that patients treated for pulmonary arterial hypertension did not achieve a statistically significant improvement in how far they were able to walk within six minutes by week 16 of the trial.
FORBES: Pharma News: United Therapeutics, Zogenix, Par Pharmaceuticals
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