However, the followup to COURAGE, the ISCHEMIA trial, will randomize ischemic patients to PCI or OMT without prior angiography.

FORBES: New Enrollment in FAME II Halted After Interim Analysis Shows Benefits of FFR

Too much of what is known about Vioxx's risks comes from so-called observational studies, which don't randomize patients to two different drugs to compare them.

FORBES: In Vioxx's Wake

Shaking the chalice to randomize the ballots is smart, but putting the ballots in a wire cage and spinning it around would be more secure -- albeit less reverent.

CNN: How secure is the papal election?

Some of these items can turn normal items into rares, turn normal items into random rarities, randomize the color of gem slots in an item, reroll the slots in an item, and more.

FORBES: Path of Exile: A Truly Free-To-Play ARPG

As a result of the positive interim analysis, the FAME II independent Data Safety Monitoring Board (DSMB) has recommended investigators stop patient enrollment in this trial as the DSMB considers it unethical to continue to randomize patients to optimal medical therapy (OMT) alone.

FORBES: New Enrollment in FAME II Halted After Interim Analysis Shows Benefits of FFR