In a 28-week study of Alzheimer's patients, 250 were in a randomized trial to memantine or placebo.
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Obviously, these findings are hypothesis-generating only and will have to be tested in a prospective, randomized trial.
On the other, there was concern regarding the lack of strong, well-executed randomized trial data of the target patient population.
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Then when a randomized trial showed that hormonal replacement therapy actually raised the early risk of heart attack, women were understandably upset.
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But sometimes, non-experimental evidence is so striking that conducting a randomized trial withholding the new intervention from half of an experimental population feels immoral.
Despite some limitations of trial design, including the open label nature of the study, RECORD remains the only randomized trial of cardiovascular outcomes for Avandia at this time.
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"I don't think there is sufficient evidence to justify a widespread change to six-times-a-week dialysis, " says Stanford University nephrologist Glenn Chertow, who is running a big, randomized trial on more frequent in-center treatment.
The gold standard for testing medical treatments is the randomized trial, in which patients are randomly assigned to a treatment or control group to spread patient differences evenly and avoid bias in results.
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The latest study, a randomized trial of 80 women and men published in Plos One by Harvard researchers, shows that even when clinicians told women with irritable bowel syndrome they are getting fake pills, the fake pills still worked.
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It is because the government-funded trial was a placebo-controlled, double-blind, randomized controlled trial.
The treatment was common until a randomized controlled trial proved it was actually harming women.
In the double-blind, randomized control trial, half the women got tenofovir gel and half got a placebo.
But there has been only one randomized controlled trial studying the effectiveness of taking foods out of so-called elimination diets, Chafen's study said.
But I think that before embarking on a large randomized controlled trial he first needs to demonstrate that such a trial would even be feasible.
In healthcare, our gold standard for good evidence is the randomized controlled trial, in which, for example, half the patients receive a new drug and half receive a placebo.
The results are the first from a major randomized clinical trial to indicate that treating an HIV-infected individual can reduce the risk of sexual transmission of HIV to an uninfected partner.
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The Cambridge group will begin a randomized controlled trial next month with 104 children involved, similar to the peanut study done already, but with controls, said researcher Dr. Andrew Clark of Cambridge University Hospitals.
Dr. Lack is in the midst of the much-anticipated, randomized controlled trial in the U.K., which is following 640 children with a high risk of allergy determined by eczema from infancy to the age of 5.
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But the RAND study side-stepped these problems by using the gold standard of scientific evidence a randomized controlled trial, just like those that the FDA relies on to provide definitive scientific evidence regarding the efficacy and safety of pharmaceuticals.
Because the Framingham Heart Study is not a randomized controlled trial, it's still not clear if vitamin D is the real reason for the link (the vitamin's levels could drop in unhealthy people for other reasons), or if taking a supplement would lower the risk.
But surgery sometimes goes mainstream without ever being evaluated in a randomized, controlled trial.
He currently is recruiting post-stroke patients for a randomized, controlled trial comparing error-type treatment to intensive treadmill training.
But a related Abbott drug, TriCor, failed to prove its benefits in a large randomized controlled clinical trial.
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Patients are now being recruited into a randomized, multicenter trial--the kind that the FDA demands before a drug can be approved.
More substantial and convincing support for such a recommendation to eat cherries as a way to reduce gout flares would ideally emerge from a randomized controlled clinical trial.
For one, the groups noted the analysis is a retrospective study, not a prospective, randomized controlled clinical trial, which many regard as a gold standard for ferreting out safety concerns.
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The RESPECT trial similarly randomized 980 patients to medical therapy or PFO closure.
The investigators are now conducting a randomized, controlled clinical trial of RAGE Control in the outpatient clinic at Boston Children's that adds a cooperative component.
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In the accepted hierarchy of evidence generation, the results of a randomized, controlled clinical trial usually take precedence over other forms of evidence such as meta-analysis and observational studies.
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In addition to his many papers exploring the basic science of the renin-angiotensin system, Matsubara was the chief investigator of the KYOTO HEART Study, a randomized, open-labeled trial studying the add-on effect of valsartan to conventional therapy in high-risk hypertension.
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