Instead of targeting thrombin directly, SCH 530348 blocks the receptor that thrombin triggers on platelets.
DeCode is now screening for compounds to target the gene and a key receptor.
Stimulating the 5-HT2C receptor alone does not appear to cause hallucinations or heart valvular problems.
It was even better when compared to the 2B (heart valve) receptor, 11.6 times more selective.
Classic drugs that cause hallucinations LSD and mescaline act by stimulating the 5-HT2A receptor.
ImClone's Erbitux blocked the EGF receptor in a slightly different way, using an injectable monoclonal antibody.
That was a dead end, but Schering was desperately seeking a thrombin receptor drug.
Veltri also had been running the development of another Schering-invented drug, the thrombin receptor antagonist vorapaxar.
Moreover, weak drugs targeting a PPAR receptor associated with heart disease have been around for decades.
DeVico's idea was to build a vaccine consisting of gp120 permanently fused to its CD4 receptor.
According to Sanofi's Ellison, the medicine blocks a receptor in the brain involved in stimulating appetite.
Dr. Brentjens and a fellow co-author hold a patent on the engineered T-cell receptor.
Instead of turning the patient's overactive dopamine receptor off, it dims it a bit.
While Sugen targeted the receptor for VEGF, Genentech was focusing on the protein itself.
Avandia works by hitting a drug target called the peroxisome proliferator-activated receptor (PPAR) gamma.
The mutation freezes a crucial protein called epidermal growth factor receptor in the "on" position.
The team also did some laboratory experiments, which showed that HIV binds to the receptor.
They blocked the D2 receptor just enough to alleviate psychoses without obliterating the patient.
Later, Kobilka isolated the specific gene that serves as a DNA blueprint for that adrenaline receptor.
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Drugs included angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs) and diuretics, with NSAIDs.
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It is associated with particular variants of receptor molecules for neurotransmitters in the brain.
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The issues relate to an oestrogen receptor test, which detects whether patients would benefit from hormone treatment.
Second-generation drugs introduced in the 1990s stick to the receptor some of the time, but not always.
This effect is assumed to be related to activation of the serotonin 2B receptor on heart tissue.
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Their original experiment used a genetic switch to regulate production of a particular receptor molecule for serotonin.
He said new therapies could be developed from orexin receptor agonists, which mimic the effect of orexin.
Eli Lilly, Abbott and AstraZeneca have run into problems with side effects in developing nicotinic receptor drugs.
Studies have since shown that stimulating the latter receptor was the reason fen-phen caused heart valve problems.
More of the tracer was floating around unbound, suggesting the receptor sites were occupied by the endorphins.
When EGF docks on a receptor, it signals to an enzyme called tyrosine kinase to regulate cell growth.
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