Rovers kept hold of striker Roque Santa Cruz in January despite overtures from Manchester City.
Roque Santa Cruz was wayward with the hosts' best chances before Adebayor headed in Denilson's cross unmarked.
Manchester United have included injury-plagued midfielder Owen Hargreaves, while striker Roque Santa Cruz makes Manchester City's roster.
Blackburn's David Bentley twice tested keeper Tim Howard and Roque Santa Cruz missed a glorious chance late on.
Yakubu headed in Arteta's cross after 64 minutes before Roque Santa Cruz slid in from close range two minutes later.
Robinho, Roque Santa Cruz and Benjani Mwaruwari are all injured and Carlos Tevez is rated extremely doubtful to face his old club.
Roque Santa Cruz is also doubtful with a hamstring injury but Benni McCarthy, Vince Grella and goalkeeper Paul Robinson are all fit.
Aside from Lescott and Sylvinho, City have also recruited Kolo Toure, Gareth Barry, Carlos Tevez, Roque Santa Cruz and Emmanuel Adebayor this summer.
Roque Santa Cruz shot wide and later passed for Benni McCarthy to slot home only for a questionable offside flag to rule the goal out.
Robinho, Roque Santa Cruz and Benjani have already been consigned to the injured list and Carlos Tevez is rated extremely doubtful to face his old club.
And with Makaay, Pizarro and Paraguay's Roque Santa Cruz already on the club's books, Van Nistelrooy's arrival "would leave us with too many strikers", according to Beckenbauer.
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Substitute Roque Santa Cruz blasted an effort over the bar after finding space on the edge of the box, but Howard was seldom called into making a save.
Villar saved from Iniesta shortly after Spain's goal, but Paraguay did have a chance to equalise late on only for Casillas to block substitute Roque Santa Cruz's effort.
The Spanish side, which was trailing by a single goal to Porto from the first leg, claimed a 2-0 win thanks to goals from Isco and Roque Santa Cruz.
Roque Santa Cruz returned to the starting XI after marking his return from a hamstring injury with a goal after coming on as a substitute at the Stadium of Light.
But Mancini - whose striking options include Carlos Tevez, Emmanuel Adebayor, Jo, Roque Santa Cruz and new-signing Mario Balotelli - is reluctant to sell Bellamy to a Premier League rival.
The Premier League and European champions have also been linked with David Silva, Thierry Henry, Klaas-Jan Huntelaar and Roque Santa Cruz, who signed a new four-year contract with Blackburn on Friday.
Within 10 days of Mancini taking over from Hughes in December 2009, Joleon Lescott, Sylvinho, Roque Santa Cruz, Stephen Ireland, Shaun Wright-Phillips, Micah Richards and Nigel De Jong all picked up injuries.
Fulham were feeling the effects of their famous win over Juventus in midweek and fell behind to first half goals from Roque Santa Cruz and Carlos Tevez, who starred for the visitors.
Malaga became the third Spanish team to advance, beating visiting Porto 2-0 for a 2-1 aggregate win as 20-year-old Francisco Alarcon scored in the 43rd minute and Roque Santa Cruz in the 77the.
Although far from its fluent best, Barcelona picked up in the second half and Gerard Pique netted four minutes after the interval only for Roque Santa Cruz to pull Malaga level once again.
If Tevez and Balotelli are missing, Mancini will be short of attacking options as Roque Santa Cruz is not in their squad list, leaving Emmanuel Adebayor and Jo as the only senior strikers.
Rovers had seen Roque Santa Cruz depart with a suspected hamstring injury shortly before the Villa opener but his replacement, Croatia striker Kalinic, did not take long to make an impact on the game.
The burden on Tevez has not been helped by the departure of Craig Bellamy, Emmanuel Adebayor's struggle for form, Mancini's reluctance to pick Roque Santa Cruz or a knee injury to new signing Mario Balotelli.
Birmingham's only lapse occurred later in the second half when Barry Ferguson, under pressure from substitute Roque Santa Cruz misplaced a back-pass straight to Tevez, but the striker shot past the far post from 10 yards.
England midfielder Gareth Barry and Paraguayan striker Roque Santa Cruz have already joined the club this summer and Argentine forward Carlos Tevez is expected to complete his move from rivals Manchester United in the near future.
Hughes, who has already spent heavily to bring Roque Santa Cruz, Carlos Tevez, Emmanuel Adebayor and Kolo Toure to Eastlands in the close season, insists the Sky Blues have acted appropriately with Everton over the England centre-half.
Shots on target could be counted one hand and the best of those came in the second half with Manchester City forward Roque Santa Cruz stinging the hands of All Whites keeper Mark Paston with a 25-yard free-kick.
Roque Santa Cruz, deployed on the right by Martino, ought to have tested Japan keeper Eiji Kawashima after a corner dropped invitingly but the striker missed from close to the penalty spot as a largely soporific half ended goalless.
Without the injured Roque Santa Cruz, Blackburn boss Paul Ince handed Robbie Fowler his first Premier League start of the season and the former Liverpool striker was keen to get on the ball early on, linking up well with Roberts and Villenueva.
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