Nadal, who was given a first round bye, recovered from losing an opening tie-break to defeat his opponent 6-7 6-2 6-2, setting-up a fourth round showdown with compatriot David Ferrer.
The Australian won their first-round encounter 4-6 7-5 6-2 to set up a meeting with Russian veteran Yevgeny Kafelnikov in round two.
Elsewhere, Juan Martin Del Potro eased past Colombia's Alejandro Falla 6-2 6-2 to set up a third round clash with France's Michael Llodra.
The Red Devils have already come through a third-round match-up at Manchester City, after a 3-2 win at the Etihad Stadium.
The 19-year-old, the youngest player left in the men's singles, swept to a 6-3 7-5 6-2 victory over the Ecuadorian to set up a fouth round match against Michael Llodra after the Frenchman beat Simone Bolelli in straight sets.
Defending champion Davide Sanguinetti brushed aside fellow Italian Giorgio Galimberti 6-2 6-4 in his first-round match to set up a meeting with Max Mirnyi of Belarus.
The 2008 finalist and seventh seed, Jo-Wilfried Tsonga demolished Slovakia's Blaz Kavcic 6-2 6-1 6-4 to set up a fourth round meeting with compatriot Richard Gasquet who also completed a straight-sets victory (6-3 7-6 6-0) over Ivan Dodig.
He set up a third round encounter with Lithuania's Ricardas Berankis after a comfortable 6-2 6-2 6-4 win against Portugal's Joao Sousa.
Gerard Greene set up a first round clash with fellow Northern Ireland star Joe Swail after enjoying a 5-2 win over Judd Trump.
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Boston was up 3-0 in the second-round series against New York this year, with a 2-0 lead in Game 4 when Rask tripped on a rut in the crease and flailed at a slow-moving puck as it rolled over the line.
The Shockers lived up to their nickname in the West, knocking off top-seeded Gonzaga in the second round and No. 2 seed Ohio State in the regional final Saturday night.
The ninth-seeded Shockers lived up to their nickname in the West, knocking off top-seeded Gonzaga in the second round and No. 2 seed Ohio State in the regional final Saturday night.
The Spaniard was the only seed to fall in the first round, while Taylor Dent, ranked 83rd in the world, set up a second-round encounter against world number one Rafael Nadal after beating Feliciano Lopez 6-3 6-2.
BBC: Andy Roddick through to Cincinnati Masters second round
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