Paul Gambaccini and a documentary strand will take the Saturday night slot vacated by Russell Brand.
Also present are Alec Baldwin, Russell Brand, Catherine Zeta-Jones, Tom Cruise, and Paul Giamatti.
Combs recently won praise for his role in Russell Brand comedy Get Him To The Greek.
Since 2007, single comedian hosts have reclaimed the show, including Andy Samberg, Aziz Ansari, Jason Sudeikis, and Russell Brand.
The temple has attracted attracted high profile guests including Boy George, Chrissie Hynde , Russell Brand and Prime Minister David Cameron.
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Host Russell Brand set the mood with an opening monologue that included no less than four jokes about the male reproductive organ.
Russell Brand voices the main character, a rabbit who would rather play the drums than do his time as the Easter Bunny.
However, he said the corporation had "shot itself in the foot" several times including over the Jonathan Ross and Russell Brand phone scandal.
Ross was suspended in October over his role in the Radio 2 phone calls row involving comedian Russell Brand and Fawlty Towers actor Andrew Sachs.
Also present, and equally obliged to sing their guts out, are Alec Baldwin, Russell Brand, Paul Giamatti, and Malin Akerman, but the honors go to Mary J.
Other winners at the ceremony, hosted by Russell Brand, included Lady Gaga for best new artist, whose live performance culminated in her pretending to stab herself and swinging from the ceiling.
Russell Brand's Hollywood Hills home was a target Monday afternoon when a 911 caller told a Los Angeles Police Department emergency dispatcher that a man with a gun was in the house.
No topic was off-limits when Conan O'Brien, Tyra Banks, Shaquille O'Neal, Seth MacFarlane, Jack Dorsey, Quincy Jones and Russell Brand discussed friendship, insecurities, success, worries, life, death and nearly everything in between.
But for now, studios are premiering smaller films like the romantic comedy Killers, starring Katherine Heigl and Ashton Kutcher, and the comedy Get Him to the Greek, featuring British comedian Russell Brand.
Ross, 48, was suspended for three months last year for his part in the Radio 2 row over lewd messages he and comedian Russell Brand left on actor Andrew Sachs' answer machine.
The mixed animation and live action film is about a man who accidentally hits the Easter Bunny (voiced by Russell Brand) with his car and then must help him recover from his injuries.
Other Comic Relief plans include a broadcast from the Give It Up For Comic Relief concert, the brainchild of Russell Brand, raising money for people in the UK affected by drug and alcohol addiction, on 6 March.
The rapper and music mogul plays a record label boss in Get Him To the Greek, which features comedian Russell Brand as wayward rock star Aldous Snow and is out in the UK on 25 June.
Back in 2008, the BBC apologized to actor Andrew Sachs after two radio presenters -- Russell Brand and Jonathan Ross -- left a series of messages on his phone while on-air, including offensive references to his granddaughter.
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In cases like the recent split of the much wealthier Katy Perry and the quirky Russell Brand, celebs who thought their marriages would last forever chose not to sign the ironclad contract and now stand to lose millions of dollars.
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Like any good brand manager, Russell Griggs, executive director of Scotland the Brand, is hoping to get consumers to associate certain desirable qualities with Scottish produce.
Anthony is part of the Jordan Brand roster, which also includes Blake Griffin, Chris Paul and Russell Westbrook.
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