"It was a safe dose of a kids' medicine, with side effect of sleepiness, " he says.

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The National Research Council has repeatedly rejected the idea that there is a safe dose.

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Among the 102 patients in the trial, 60% of those who got the highest safe dose avoided severe disability, compared with 22% of those who got a placebo.

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We do know that caffeine is safe in lower dose ranges from 100-300 mg a day, which is typically contained in several cups of coffee.

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It is possible, Nissen says, that Celebrex could be safe at its labeled dose of 200 mg.

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The federal government has insisted ever since the TSA decided to install 300 full-body scanners, or strip searchers as critics call them, that getting a small dose of radiation is safe.

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"I think the A to Z trial pushed the dose of a good drug beyond its safe limits, " says Steven Nissen, a cardiologist at the Cleveland Clinic who wrote a blistering commentary about A to Z in JAMA. "The study falls far short of acceptable scientific evidence, " Nissen says.

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"As long as you use the customary dose, I'm encouraged that it might be a safe alternative, " Nissen says.

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