Other work on the effects of caloric restriction, consuming red wine and altering genes in yeast, mice and nematodes has shown promise in slowing senescence.
Research shows that exercise can help to maintain physical function late in life and that exercising one's brain can limit the progression of senescence.
Existing lines of inquiry into prolonging lifespan are based either on removing the Hayflick limit, which would have all sorts of untoward consequences, or suppressing production of the oxidative chemicals that are believed to cause much of the cellular damage which is bracketed together and labelled as senescence.