Dr. Snyder may have found one in his serendipitous discovery of how D-serine functions.
D-serine was of the "right-handed" configuration, which is almost never seen in the human body.
D-serine had a "right-handed" configuration, which is almost never seen in the human body.
Snyder may have found one in his serendipitous discovery of how D-serine functions.
And since D-serine is so rare, researchers hope drugs that thwart its production won't have unwanted effects elsewhere in the body.
Guilford has already concocted D-serine blocking compounds and will soon begin animal tests to see whether they live up to their promise.
Snyder's team has isolated the key enzyme involved in producing D-serine.
His team has isolated the key enzyme involved in producing D-serine.
And their new paper identifies the enzyme, called serine racemase, that converts left-handed serine into the right-handed form so that it can do its job.
In the past year Snyder's lab has conducted a series of experiments that suggest D-serine acts in concert with glutamate to stimulate nerve cells to fire.
In the past year his lab has conducted a series of experiments that suggest that D-serine acts in concert with glutamate to stimulate nerve cells to fire.
Dr. Snyder believes D-serine is there as a fail-safe to make sure memory cells spring into action only when they are supposed to--a process that breaks down during a stroke.
Snyder believes that D-serine is there as a fail-safe to make sure that memory cells spring into action only when they are supposed to--a process that breaks down during a stroke.
Several years ago he read a paper in a scientific journal by a Japanese scientist who had discovered D-serine in key areas of the brain but didn't know why it was there.
Several years ago he read in a scientific journal a paper by a Japanese scientist who had discovered D-serine in key areas of the brain but didn't know why it was there.
By blocking these errant molecules, D-serine and poly ADP-ribose polymerase (PARP), researchers may be able to stop brain cells from dying while avoiding the toxic side effects that have plagued previous experimental treatments.
By blocking these errant molecules, called D-serine and poly ADP-ribose polymerase, known as PARP, researchers may be able to stop brain cells from dying, while avoiding the toxic side effects that have plagued previous experimental treatments.
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