Amicus and Shire teamed today to address some of the same markets that Genzyme targets.
Exactly this same anxiety extends to other shire counties, far beyond the Staffordshire Moorlands.
Consequently, they are being marginalised as the party of the shire counties and the nostalgic elderly.
The sites identified for possible development are Teaninich, Ross-shire, and Glendullan and Inchgower, both on Speyside.
The decision is a setback, of course, given that Shire has emphasized treating rare diseases.
Shire plan a minute's silence before Saturday's Scottish Football League match at home to Peterhead at Ochilview.
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Drinks giant Diageo has announced plans for a major expansion of its Glen Ord distillery in Ross-shire.
Warsame Shire Awale, a writer, singer, comedian and radio personality, worked as a satirist for Radio Kulmiye.
Details on one interesting one were revealed in the purchase of a company called Lotus Tissue Repair by Shire.
Either on your way to or from the island, stopping off at Kishorn Seafood Bar, Ross-shire, is a must.
In fact, Shire believes more than 1, 000 patients have switched to Replagal since the Genzyme shortage began in 2009.
"It is not a hybrid, " says John Mckenzie, a 38-year-old helicopter pilot who owns a farm near Dingwall in Ross-shire.
Shire has moved into the field in a big way, and Novartis and Pfizer look likely to follow.
The firm is also expanding at Muir of Ord in Ross-shire and it is building new warehousing near Kirkcaldy in Fife.
Joan Elizabeth Ross , JP (Invergordon, Ross and Cromarty) - For services to Business and to the community in Alness, Ross-shire.
Tesco already has permission to build a store in the Ross-shire town.
Shire no longer produces the instant release (IR) form of the drug.
Paulson initiated a Shire Plc position in the third quarter of 2012.
Shire research is aimed at developing an enzyme-replacement therapy, while the planned research at Nationwide Children's will focus on potential gene therapy.
The family will need to make the trip three times for the study, which is sponsored by biopharmaceutical company Shire PLC.
The company is well known for its traditional Shire horse drawn wagons.
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Tolkien's fictional shire, whose denizens maintain a voluntary, ordered society where the sense of fellowship is strong and where government is small.
Other major players include Alexion Pharmaceuticals, BioMarin, and Shire PLC.
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Shire says it has presented some data from its Sanfilippo studies at scientific conferences and will eventually publish the information in scientific journals.
In 1878, ownership and operation of the prison was transferred from the shire authorities to the Home Office, as Her Majesty's Prison, HMP Oxford.
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The CIPD says shire councils could also introduce different pay for their teachers depending on whether they worked in a rural or urban area.
Of course, Shire may also calculate there is less upside now that Fabrazyme production has resumed and passing the FDA gauntlet could become expensive.
Ironically, the agency encouraged Shire to enter the Fabry disease market in the US in the wake of protracted quality-control problems encountered by Genzyme.
The company is famous for its traditional Shire horse drawn wagons.
Among the candidates for the stockmarkets top honours is a raft of former Footsie members, among them Shire Pharmaceuticals, Associated British Foods, Rolls-Royce, Hanson and Psion.
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