On Sunday, he beat Rafael Nadal in the Rome Masters, his fourth-straight win over the Spaniard.
The Spaniard, who had heavy strapping on both knees, needed treatment for tendonitis during the match.
The Spaniard's father Emilio de Villota was also an F1 driver between 1976 and 1982.
"It was a tough match and I was never really close, " said the Spaniard.
Nine of the last 12 French Open finals have featured at least one Spaniard.
But the favourite was comprehensively beaten in four sets by his fellow Spaniard Albert Costa.
The Spaniard has been out of work since being sacked by Inter Milan in January 2011.
And in the pit lanes the Spaniard could not even dismount his bike without assistance.
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The Spaniard's last defeat in this event was against Guillermo Coria 10 years ago.
"I think we're very happy as we know Friday means very little, " said the Spaniard.
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Vettel beat Ferrari's Fernando Alonso by 0.076 seconds, with the Spaniard's team-mate Felipe Massa in third.
The Spaniard did not face a single break point and lost just 10 points on serve.
Its force commander, an experienced Spaniard, has resigned in despair seven weeks after taking over.
But the Spaniard, despite making a perfect start, was not at his absolute best on Friday.
The Spaniard is joined by South Africa's Charl Schwartzel and America's Keegan Bradley and Michael Thompson.
The Spaniard now has a tour-leading 74 match wins this year, one more than Djokovic.
Wenger selected Fabregas despite the Spaniard's on-going fitness troubles and admitted it had been a gamble.
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Roberto Soldado, who had put Valencia ahead, was also quick to praise his fellow Spaniard.
The Spaniard won last year's Tour de France by 39 seconds from Luxembourg's Andy Schleck.
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Philippoussis will now face Sjeng Schalken of the Netherlands, who beat 14th-seeded Spaniard Albert Costa.
"Sometimes you have to spend a little bit more, " the Spaniard told Press Association Sport.
So too is Carlos Westendorp, a Spaniard who has been representing the West in Bosnia.
Both Spaniard Moya and fourth-seeded Grosjean had had byes in the first round of the claycourt tournament.
After his shock defeat, the Spaniard took a prolonged break to recover from tendinitis in both knees.
He is also the third Spaniard running to win the event after Jimenez (2003) and Garcia (2004).
The Spaniard, who has won the last eight Monte Carlo tournaments, starts his defense against Marinko Matosevic.
Fourth-seeded Spaniard Montanes moved into the last four by beating Uruguayan eight seed Pablo Cuevas 6-4 6-3.
The Spaniard is ahead of British rider Bradley Smith and Italy's Andrea Iannone, who leads the championship.
The Spaniard showed no nerves as he struck the ball past Green to cap a magnificent display.
But Schuettler hit back impressively, breaking the formidable Spaniard's serve in game three of the second set.
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