The greatest damage from Vioxx may have been to the subpopulation of arthritis sufferers already predisposed to having a heart attack.

FORBES: Just Say No--to Drug Lawsuits

This subpopulation of 30, 000 (in a country of 22.7 million) includes some 5, 000 princes who control virtually all aspects of government and the military.

FORBES: The prize

You would try to treat as many people as possible and hope that you could identify a subpopulation of people that would respond to your drug.

FORBES: Using Stem Cells To Identify Better (And Cheaper) Drugs