He has been on tour night after night and it does take its toll.
The real estate bubble, stoked by the eurozone's low interest rates, continues to take its toll.
It may take a while for the uncompetitive pricing to take its toll in customer departures.
Manager Tony Mowbray admitted to The Times newspaper the traveling does take its toll.
Numerous studies have shown that stress can take its toll on the human body.
It really does need highlighting that winter can take its toll in this way, particularly on the elderly.
But recent data suggest that the weakening American economy is now starting to take its toll to the north.
Jackie Sanders says the combination of physical and emotional strain, combined with the lack of sleep, can take its toll.
There are so many good fringe meetings and interesting people to meet but it is beginning to take its toll.
The figure represented an increase of 1.1 % from the previous quarter, as recession continues to take its toll on the debt-stricken nation.
The accumulated fatigue of being on the road for a long time - even for "home" matches - had started to take its toll.
My growing cynicism began to take its toll, and I began hating myself for working to support an education system that I saw as corrupt.
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Severe weather also continues to take its toll in the Alps , where a number of skiers have been killed in avalanches since the weekend.
Welcome to the high-pressure world of Liverpool manager Rafael Benitez - one that is, according to one expert, starting to take its toll on the Spaniard.
As my colleague Morgan Brenan has explained, Hurricane Sandy was expected to take its toll on housing and construction, which could exacerbate seasonal slowness characteristic of the winter season.
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While the strike at Cerro Verde has not had affected production as seriously as Grasberg, Freeport is working with a skeleton crew of workers which could eventually take its toll on production.
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Prices of RNF shares moved higher by about 50% from August to February, but have nose dived since then as the higher price of natural gas has begun to finally take its toll.
In the last six months, this has changed, however, as foreign investors begin to realize that the Chinese economy may be in for a hard landing that may take its toll on banks.
Health problems hit in 1997 when Parfitt's old lifestyle of drink and drugs began to take its toll and he underwent a quadruple heart bypass after doctors warned he could die at any time.
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In the U.S., the fiscal cliff debacle promises to take its toll on markets, much like the debt ceiling debate which resulted in a credit rating downgrade and a massive risk asset correction last year.
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The second term can take its toll, he went on, quipping that he's tried taking inspiration from his wife, Michelle -- but bangs don't really work on the commander-in-chief, as photos displayed on the screen proved.
The two middleweights spent the majority of the bout trading blows, although the furious pace they set began to take its toll on the fighters in the fifth round as Stevens and Findley engaged in clinches following exchanges.
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Putting that triumph at risk will take its greatest toll on the very individuals whom the NYPD's critics purport to speak for.
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The heat and the dust could take its own toll.
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The study was particularly noteworthy because alarmists claim ocean acidification will take its greatest toll on marine invertebrates such as sea stars, which will allegedly have more difficulty calcifying their external skeletons in water with more carbon dioxide.
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Its weight didn't take an immediate toll on this editor's arms, but some light fatigue was noticeable after about 20 or 30 minutes of play.
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