But Fisher recognised that cranking up the dosage makes no difference if you are using the wrong medicine.
Linda Beale for example is absolutely adamant that the taxation of investment returns makes no difference at all to how much people will invest.
They know that these arrangements make a difference, but they also know that the explanation makes no sense or makes them angry.
But he says that, in the end, it makes no difference whether his party is registered or not.
Whether that makes up the difference or not (Mojo says no) remains to be seen.
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They determined that only one in a hundred bank branches is robbed in any year and that the location and size of the branch makes no discernible difference.
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What is really being said here is that if Greece leaves then Greece can, quite legally, simply state that all debts contracted under Greek law can now be settled in the New Drachma and the fact that this is worth less than the old euros makes no difference.
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"There is no doubt that having a settled defence makes all the difference to us, " he said.
It makes no difference whether we have a magic box that simply spouts electricity, some foreigners make it for us or we make it.
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And they need to do this whilst standing head and shoulders above competitors with a true standout campaign that is no one-hit-wonder, and which makes a real difference, securing consumer loyalty for life.
Despite all this, some libertarians continue to insist that, because the Republican and Democrats are equally bad for liberty, it makes no difference who gets elected.
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