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These are normally produced by the adrenal gland, but damage can cause levels to drop.
BBC: Living with Addison's disease
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The disease is normally caused by the body's own immune system turning on the adrenal gland, but cancer and tuberculosis can also trigger the condition.
BBC: Living with Addison's disease
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The patient was a woman with a large tumor in the adrenal gland atop her right kidney, and I had decided to remove it using a laparoscope.
NEWYORKER: Personal Best