This summer, hopes were high for the company because it was selling generic versions of paclitaxel, the powerful cancer-fighting drug that Bristol-Myers Squibb (nyse: BMY - news - people) sells under the brand name Taxol.

FORBES: Magazine Article

But there were also high hopes, fuelled by the thought of vast quantities of underused brainpower and raw materials that were now joining the world economy.

ECONOMIST: A survey of Russia

But his hopes of ending the century on a high were shattered when a thigh muscle injury saw him pull out of the Paris Open in November, so ending his chances of booking a place in the season-ending ATP World Championships.

BBC: New injury blow for Rusedski

When Vicente Fox took office as Mexico's president in December 2000, hopes were high that he would transform the nation from a corruption-tainted, slow-moving bureaucracy into a vibrant, safer country overflowing with entrepreneurship.

FORBES: The Mexico That Might Have Been

Hopes for a picturesque descent near the Great Pyramids were dashed by high winds.

BBC: Desert touchdown for balloon heroes

There were high hopes originally for Schapiro, who had plenty of regulatory experience running the Commodity Futures Trading Commission and the Financial Industry Regulatory Authority.

FORBES: Mary Schapiro Out At The SEC

He makes fleeting allusions to his periods of wayward behavior, which he regrets, and his high hopes for a real-estate venture in Spain were blasted by the global recession, which he had predicted with fateful accuracy.

WSJ: Film Review: Life, Not by the Numbers by Joe Morgenstern

Serbia's hopes of joining the EU were for many years frozen pending the capture of two of the Bosnian war's most high-profile war crimes suspects, Radovan Karadzic and Ratko Mladic.

BBC: Serbia recommended for EU candidate status

Steven Gerrard, Glen Johnson and Dirk Kuyt were not even in the home side's squad and Trabzonspor coach Senol Gunes would have had high hopes of earning a measure of revenge over the Merseysiders.

BBC: Liverpool 1-0 Trabzonspor